| 野生山葡萄皮渣多酚类物质对老龄大鼠脑脂褐素的影响 |
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| 引用本文： | 焦淑萍,姜虹,陈彪,高维明.野生山葡萄皮渣多酚类物质对老龄大鼠脑脂褐素的影响[J].北华大学学报(自然科学版),2003,4(2):127-129. |
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| 作者姓名： | 焦淑萍 姜虹 陈彪 高维明 |
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| 作者单位： | 1. 北华大学,医学院,吉林,吉林,132001
2. 大连医科大学,丹东分校,辽宁,丹东,118002 |
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| 基金项目： | 吉林市科委基金项目(吉科合字2000330号) |
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| 摘 要： | 目的 研究野生山葡萄皮渣总多酚(PVAS)的抗衰老作用．方法 PVAS按每d200mg/kg，400mg/kg给老路大鼠连续灌胃30d，到血清MDA含量、SOD活性和脑组织脂褐素含量．结果 PVA(每d200mg／kg，400mg／kg，共30d)组均能显著降低老龄大鼠血清MDA和脑组织脂褐素含量(P＜0．05)．PVA(400mg／kg)能明显提高老龄大鼠血清SOD活性（P＜0．05)．结论 PVA能有效地改善自由基代谢，具有抗衰老作用．
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| 关 键 词： | 野生山葡萄皮渣总多酚 抗衰老作用 脂褐素 自由基代谢 多酚类物质 老龄大鼠 脑组织 |
| 文章编号： | 1009-4822(2003)02-0127-03 |
| 修稿时间： | 2002年10月9日 |
Effect of the Polyphenols of Vitis Amurensis Rupr Skin and Seed (PVAS) on Lipofuscin of Cerebral Tissues in Wistar Elderly Rats |
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| JIAO Shu-ping,JIANG Hong,CHEN Biao,GAO Wei-ming.Effect of the Polyphenols of Vitis Amurensis Rupr Skin and Seed (PVAS) on Lipofuscin of Cerebral Tissues in Wistar Elderly Rats[J].Journal of Beihua University(Natural Science),2003,4(2):127-129. |
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| Authors: | JIAO Shu-ping JIANG Hong CHEN Biao GAO Wei-ming |
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| Abstract: | Objective To observe antiaging actions of PVAS. Methods 200 and 400 mg/kg of PVAS were given to the old rats every day for thirty days. The content of malon-dialdehyde (MDA) and the activity of superoxide dismutase (SOD) in serum, the content of lipofuscin in brain were examined. Results PVAS (200,400 mg/kg) could decrease significantly the content of MDA in serum and the content of lipofuscin in brain of the old rats(P<0.05) . PVAS(400 mg/kg) could increase significantly the activity of SOD in serum of the old rats(P<0. 05). Conclusion The results suggest that PVAS may produce antiaging action and improve metabolism of free radicals. |
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| Keywords: | Polyphenols of Vitis amurensis Rupr skin and seed Antiaging action Lipofuscin |
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