| 白花蛇舌草体外对人肝癌多药耐药细胞Bel-7402抗肿瘤活性的研究 |
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| 引用本文： | 于春艳,李薇,刘玉和,盖小东,张维瑜,陆军.白花蛇舌草体外对人肝癌多药耐药细胞Bel-7402抗肿瘤活性的研究[J].北华大学学报(自然科学版),2004,5(3):221-223. |
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| 作者姓名： | 于春艳 李薇 刘玉和 盖小东 张维瑜 陆军 |
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| 作者单位： | 北华大学医学院,吉林,吉林,1320O1;北华大学医学院,吉林,吉林,1320O1;北华大学医学院,吉林,吉林,1320O1;北华大学医学院,吉林,吉林,1320O1;北华大学医学院,吉林,吉林,1320O1;北华大学医学院,吉林,吉林,1320O1 |
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| 摘 要： | 目的探讨白花蛇舌草在体外对肝癌多药耐药细胞Bell-7402生长活性的抑制作用.方法 MTT法检测白花蛇舌草提取物对Bel-7402生长的抑制作用,有无逆转Bel-7402的多药耐药性;用淋巴细胞转化实验检测白花蛇舌草提取物能刺激T淋巴细胞增殖,并筛选出药物的安全剂量范围;集落形成实验观察体外抗癌药物的敏感性.结果白花蛇舌草提取物对肝癌多药耐药细胞Bel-7402的生长具有明显的抑制作用,且这种作用是剂量依赖关系.结论白花蛇舌草提取物在体外对人肝癌多药耐药细胞Be1-7402有抑制作用.
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| 关 键 词： | 白花蛇舌草 Bel-7402 淋巴细胞转化 多药耐药 |
| 文章编号： | 1009-4822(2004)03-0221-03 |
| 修稿时间： | 2003年11月16日 |
Anti-tumor Effects of Oldenlandia Diffusa on Multidrug Resistance of Human Hepatic Cancer Cell Bel-7402 in Vitro |
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| YU Chun-yan,LI wei,LIU Yu-he,GAI Xiao-dong,ZHANG Wei-yu,LU Jun.Anti-tumor Effects of Oldenlandia Diffusa on Multidrug Resistance of Human Hepatic Cancer Cell Bel-7402 in Vitro[J].Journal of Beihua University(Natural Science),2004,5(3):221-223. |
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| Authors: | YU Chun-yan LI wei LIU Yu-he GAI Xiao-dong ZHANG Wei-yu LU Jun |
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| Abstract: | ObjectiveTo investigate the anti-tumor effects of Oldenlandia Diffusa on multidrug resistance of human hepatic cancer cell Bel-7402 in vitro.MethodsGrowth inhibition was measured by MTT assay, which the reverse effects on multidrug resistance of Bel-7402 was also determined. Oldenlandia Diffusa markedly stimulated lymphocytes to proliferate. The safety dosage range of this herb was screened out. The sensitivity of anti-tumor effect in vitro was observed by clony-forming test.ResultsGrowth inhibitory effect in a dose-dependent manner on multidrug resistance of human hepatic cancer cell Bel-7402 was strongly displayed by using Oldenlandia Diffusa.ConclusionOldenlandia Diffusa plays an important role in the anti-tumor effect on multidrug resistance of human hepatic cancer cell Bel-7402 in vitro. |
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| Keywords: | Oldenlandia Diffusa Bel-7402 Lymphocyte transformation Multidrug resistance |
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