| 远志茯苓醇提物改善学习记忆障碍的实验研究 |
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| 引用本文： | 李富仁,丑莉莉,范新田.远志茯苓醇提物改善学习记忆障碍的实验研究[J].北华大学学报(自然科学版),2011(2):172-176. |
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| 作者姓名： | 李富仁 丑莉莉 范新田 |
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| 作者单位： | 北华大学基础医学院;北华大学医学检验学院;北华大学药学院; |
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| 基金项目： | 卓怡康纳中药研发基金项目(ZY040301) |
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| 摘 要： | 目的 通过观察中药远志茯苓醇提物对学习记忆障碍动物模型的影响,研究其改善学习记忆障碍的药理作用,并探讨其作用机制,为中药远志茯苓能够预防和治疗老年性痴呆即阿尔茨海默病提供可靠的依据.方法 通过避暗法观察远志茯苓醇提物对东莨菪碱所致记忆获得性障碍模型小鼠的影响;通过跳台法观察远志茯苓醇提物对30%乙醇所致记忆再现障碍模型...
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| 关 键 词： | 远志茯苓醇提物 学习记忆 乙酰胆碱酯酶 阿尔茨海默病 |
Experimental Studies on Effects of EEPP on Learning and Memory Dysfunctions |
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| LI Fu-ren,CHOU Li-li,FAN Xin-tian.Experimental Studies on Effects of EEPP on Learning and Memory Dysfunctions[J].Journal of Beihua University(Natural Science),2011(2):172-176. |
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| Authors: | LI Fu-ren CHOU Li-li FAN Xin-tian |
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| Institution: | LI Fu-ren1,CHOU Li-li2,FAN Xin-tian3(1.Basic Medical College of Beihua University,Jilin 132013,China,2.Medical Inspection College of Beihua University,3.Pharmacy College of Beihua University,China) |
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| Abstract: | Objective To observe the behavioral effects of Ethanol extract of Polygala tenuifolia and Poria cocos(EEPP)on learning and memory dysfunctions induced by chemical agents in mice and study its possible mechanisms to provide theoretical evidence for the prevention and treatment of Alzheimer's disease(AD).MethodEffects of EEPP on acquired learning and memory disorders induced by scopolamine in mice were observed by using step-through test;Effects of EEPP on reappeared memory disorder induced by 30% alcohol in ... |
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| Keywords: | EEPP(Ethanol extract of Polygala tenuifolia and Poria cocos) Learning and memory Acetylcholinesterase(AChE) Alzheimer's disease(AD) |
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