米索前列醇不同给药途径用于早孕人流术前宫颈扩张的效果分析

目的探讨米索前列醇不同给药途径用于早孕人流术前宫颈扩张的疗效.方法将停经≤60 d要求手术终止妊娠的150名健康初孕妇女随机平均分为3组,A组在人工流产术前3 h舌下含服米索前列醇,B组在人工流产术前3 h阴道放置米索前列醇,C组作为对照组术前未予任何药物,A,B组用药后3 h行人工流产术.记录观察对象用药后副反应、术中宫颈扩张度、手术时间和术中出血量.结果A,B组在用药后副反应比较,A组胃肠道反应发生率高于B组(P<0.05),但术前阴道出血和下腹痛发生的比率B组高于A组,差异无显著性(P>0.05),A,B组在术中宫颈扩张度、手术时间和术中出血量比较差异无显著性(P>0.05),但与对照组(C组)比较有显著性差异(P<0.05).结论人工流产术前舌下含服或阴道放置米索前列醇均可有效扩张宫颈,阴道放药虽然胃肠道反应小一些,但舌下含服米索前列醇方法方便,更容易为广大孕妇接受.

Effect of Different Misoprostol Administered Approaches for Cervical Ripening before Artificial Abortion of First-trimester Pregnancy

Objective To assess the efficacy of different misoprostol administered approaches for cervical ripening before artificial abortion of first-trimester pregnancy.Methods 150 women who asked for termination of pregnancy with a normal intrauterine pregnancy before 60 days'gestation were divided randomly into three groups.Group A took sublingual misoprostol 3 hours ago at the beginning of operation;group B were put into vaginal misoprostol 3 hours ago;group C were not given any medicine.To observe side-effect,degree of cervical dilatation,operation time and amount of blood.Results The side effects were compared in Group A and B,more women in group A showed gastrointestinal side effects(P<0.05),but there were more women in group B complained hypogastralgia and vaginal bleeding before operation,there was no significant(P>0.05).The degree of cervical dilatation,operation lasting time,the amount of blood in group A or B was obviously different from group C(P<0.05),and there was no significant difference among group A,B(P>0.05).Conclusion Misoprostol that were sublingualed or put into vaginal were effective in cervical ripening before artificial abortion of first-trimester pregnancy.The group put misoprostol into vaginal showed rarely gastrointestinal,but the method of sublingual misoprostol was convenient,it was easily took by women.