| 新型相转移催化剂的合成及其在不对称合成中的应用 |
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| 引用本文： | 王振雷,刘全忠,何龙,肖吉富.新型相转移催化剂的合成及其在不对称合成中的应用[J].西华师范大学学报(哲学社会科学版),2007,28(2):177-180. |
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| 作者姓名： | 王振雷 刘全忠 何龙 肖吉富 |
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| 作者单位： | [1]西华师范大学化学化工学院,四川南充637002 [2]营山中学,四川营山637002 |
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| 摘 要： | 烷基化反应被认为是最有用的碳-碳键形成的反应之一．作者以光学纯的联二萘酚为原料经过与三氟甲烷磺酸酐成酯反应，与甲基格氏试剂发生偶联反应，经甲基保护酚羟基后溴代，最后与生物碱反应制备手性相转移催化剂．在二苯甲酮亚胺甘氨酸叔丁酯的不对称烷基化反应中，2mol％催化剂用量，获得较高的产率和27％的对映选择性．
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| 关 键 词： | 二苯甲酮亚胺甘氨酸叔丁酯 相转移催化剂 不对称烷基化 |
| 文章编号： | 1673-5072（2007）02-0177-04 |
| 修稿时间： | 2006-12-30 |
Syntheses of New Quaternary Ammonium Phase Transferred Catalysts and Their Application in Enantioselective Alkylation |
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| WANG Zhen-lei, LIU Quan-zhong, HE Long , XIAO Ji-fu.Syntheses of New Quaternary Ammonium Phase Transferred Catalysts and Their Application in Enantioselective Alkylation[J].Journal of China West Normal University:Natural Science Edition,2007,28(2):177-180. |
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| Authors: | WANG Zhen-lei LIU Quan-zhong HE Long XIAO Ji-fu |
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| Institution: | 1. College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China; 2. Yingshan High School, Nanchong 637002, China. |
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| Abstract: | The alkylation reaction is of great importance in the formation of C-C bond.A new type of chiral phase-transfer catalysts has been synthesized starting from BINOL.Optically pure B1NOL was reacted with triflic anhydrine to yield the ester,which was coupled with methlmagnesium iodides.After protection of the alkoxy functions using Mci was was convened to the bromo derivative,and sequentially the reaction with cinchona alkaloid gave the phase-transfer catalysts.The application of the PTC(2 mol %) in the alkylation of N-(diphenylmethylene)glycine t-butyl ester gained good yields even up to 27%. |
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| Keywords: | N-(diphenylmethylene)glycine t-butyl ester phase-transfer catalysts asymmetric alkylation |
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