Enhanced structural stability of adenovirus nanocapsule |
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| Authors: | Ding Weng Ziyue Karen Jiang Jing Jin Lily Wu Yunfeng Lu |
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| Institution: | Chemical and Biomolecular Engineering, University of California at Los Angeles;Tissue Engineering Laboratories, VA Boston Healthcare System;Department of Orthopaedic Surgery, Brigham and Women’s Hospital, Harvard Medical School;Molecular and Medical Pharmacology, University of California at Los Angeles;Getein Biotechnology Co., Ltd. |
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| Abstract: | Application of viral vector in gene therapy and vaccination is still limited by their structural stability, which significantly increased avoidable cost in storage and transportation. Herein a non-covalent conjugated low-pH degradable nanocapsule has been adopted to stabilize viral vectors. By utilizing a luciferase expressing adenovirus, AdCMVLuc, we succeeded in a raise of over 11 folds in AdCMVLuc׳s structural stability after 12 days storage at 4 °C. |
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| Keywords: | Non-covalent nanocapsule Adenovirus Structural stability |
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