Synergistic actions of complement and lysozyme in clearance of Escherichia coli from amphioxus Branchiostoma belcheri |
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Authors: | Guangfeng Wang Shicui Zhang Zhimeng Zhuang Zhiping Wang |
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Institution: | a) Department of Marine Biology, Ocean University of China, Qingdao 266003, China;
b) Yellow Sea Fisheries Research Institute, Qingdao 266071, China |
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Abstract: | Amphioxus appears lacking free circulating blood cells. How it clears invading pathogens from its body remains unknown to date. We demonstrate here that amphioxus Branchiostoma belcheri is capable of efficiently eliminating the invading bacterium Escherichia coli from its humoral fluid, and the complement and lysozyme are both involved in the elimination of the invading pathogen. Both the complement and lysozyme act in concert against the invading bacterium, but the complement appears playing a more dominant role than the lysozyme. |
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Keywords: | Amphioxus Branchiostoma Complement Lysozyme Humoral fluids Anti-bacterial activity |
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