| 生物活性梯度涂层的结构与动物实验 |
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| 引用本文： | 王迎军,宁成云,吴建青,李尚周,叶建东,赵娜如,何智勇,廖威明,何爱珊,李佛保.生物活性梯度涂层的结构与动物实验[J].华南理工大学学报(自然科学版),2002,30(4):23-25,36. |
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| 作者姓名： | 王迎军 宁成云 吴建青 李尚周 叶建东 赵娜如 何智勇 廖威明 何爱珊 李佛保 |
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| 作者单位： | 1. 华南理工大学,材料科学与工程学院,广东,广州,510640
2. 中山大学,附属第一医院,广东,广州,510080 |
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| 基金项目： | 国家自然科学基金资助项目 (5 9932 0 5 05 9872 0 10 )，广东省自然科学基金资助项目 (980 5 5 1) |
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| 摘 要： | 采用先进的表面技术复合制备生物活性梯度涂层材料。通过与rhBMP-2生物组装获得具有骨诱导功能的复合人工骨材料，这种材料在植入动物体内3周后即可形成大量的新生骨细胞和骨组织，新生骨组织沿着涂层的微孔长入，与涂层结合紧密。16周后新生骨组织矿化均匀，形成比较成熟的、排列有序的层板编织骨。作为对比研究的金属钛合金植入体与骨组织结合的界面中只是形成大片的纤维组织，而未见新生骨组织。
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| 关 键 词： | 生物活性 梯度涂层 结构 动物实验 材料 |
| 文章编号： | 1000-565X(2002)04-0023-04 |
Structure Desigin and Animal Experiment on Bioactive Gradient Coating |
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| Wang Ying_jun,Ning Cheng_yun,Wu Jian_qing,Li Shang_zhou,Ye Jian_dong,Zhao Na_ru,He Zhi_yong,Liao Wei_ming,He Ai_shan,Li Fo_bao.Structure Desigin and Animal Experiment on Bioactive Gradient Coating[J].Journal of South China University of Technology(Natural Science Edition),2002,30(4):23-25,36. |
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| Authors: | Wang Ying_jun Ning Cheng_yun Wu Jian_qing Li Shang_zhou Ye Jian_dong Zhao Na_ru He Zhi_yong Liao Wei_ming He Ai_shan Li Fo_bao |
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| Institution: | Wang Ying_jun 1 Ning Cheng_yun 1 Wu Jian_qing 1 Li Shang_zhou 1 Ye Jian_dong 1 Zhao Na_ru 1 He Zhi_yong 2 Liao Wei_ming 2 He Ai_shan 2 Li Fo_bao 2 |
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| Abstract: | The HA gradient coating on Ti alloy substrate was developed using PVD and plasma spraying techniques. The coating was assembled with rhBMP_2 to obtain a new type of composite artificial bone materials which possesses osteoinductive function. The implantation into animal indicated that a large amount of new generative bone cells and bone tissue were formed on the top layer of the coating in 3 weeks after the implantation. The new generative cartilage and bone tissues had grown into the pores on the top layer of the coating and bonded to the coating firmly. In 16 weeks after the implantation, the new generative bone tissue was mineralized homogeneously and relative mature and order_arranged laminar woven bone were formed. As a comparison, the uncoated Ti alloy rods showed very different implanting result: only the piece_like fibrous tissue could be observed in 16 weeks after the implantation and no new generative bone tissue was found. |
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| Keywords: | gradient coating bioactive bone morphogenetic protein osteoinduction |
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