| 生物降解材料—聚乙交酯医用纤维的研究 |
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| 引用本文： | 赵耀明,黄俊豪.生物降解材料—聚乙交酯医用纤维的研究[J].华南理工大学学报(自然科学版),1994,22(6):71-79. |
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| 作者姓名： | 赵耀明 黄俊豪 |
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| 作者单位： | 华南理工人学轻化工程系 |
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| 摘 要： | 以乙醇酸为原料，合成α－乙交酯单体，进而再聚合成生物降解聚合物聚乙交酯（ＰＧＡ）。对聚合物进行纺丝成形，获得ＰＧＡ纤维。应用红外光谱（ＩＲ）、差示扫描量热分析（ＤＳＣ）、热重分析（ＴＧＡ）和Ｘ－射线衍射法，研究聚乙交酯的结构和性能。通过对ＰＧＡ纤维的生体内外的降解试验，发现其降解速度随浸渍液的ｐＨ值的增加而增大，特别是在碱性介质中重量损失最为明显。ＰＧＡ纤维埋入ＳＤ大白鼠体内，对机体无毒性，组织反应极小，６０天后能被机体完全吸收，对机体具有良好的相容性。
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| 关 键 词： | 缝合线 生物降解 医用高分子材料 聚乙交酯 手术 |
BIODEGRADABLE MATERIALS OF POLYGLYCOLIDE AS A MEDICAL FIBER |
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| Zhao Yaoming, Huang Junhao, Chen Junwu, Zhuang Huiqing, Huang Ziguo.BIODEGRADABLE MATERIALS OF POLYGLYCOLIDE AS A MEDICAL FIBER[J].Journal of South China University of Technology(Natural Science Edition),1994,22(6):71-79. |
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| Authors: | Zhao Yaoming Huang Junhao Chen Junwu Zhuang Huiqing Huang Ziguo |
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| Abstract: | Polyglycolide(PGA) was prepared using a-glycolide Which was synthesizedfrom glycolic acid. The fiber of PGA was spun with a capillary rheometer. The strUctureand properties of PGA were investigated by infrared spectrtLm(IR), differential scanning calorimeny (DSC),thempgravetric analysis (TGA), andX- raydifflaction.Thedegradation rate of the PGA fiber increases with increasing PH and the weight lossbecomes most obvious in alkaline medium. The embedment of the PGA fiber in thebody of SD rats shows that PGA polymer is non-toxic and can be absorbed completely by a rat body after 60 days. |
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| Keywords: | s: polyesters hydroxy-ethanoic acid(p) sutural line biological degradation medical macromolecular materials /glycolide |
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