一种新型心肺复苏术血流动力学效果的模型研究

目的-用血液循环系统仿真模型来检验新型复苏术Active Compression-Decompression CPR with Enhanced External Counterpulsation and the Inspiratory Impedance Threshold Valve (AEI-CPR)的作用机制和血流动力学效果。方法-计算机仿真模型模拟人体在正常情况、心脏骤停以及采取新型复苏术后的血流动力学效果。为了比较和验证新型复苏术AEI-CPR的效果，几种典型复苏术分别作用于同一循环系统模型进行仿真，包括：标准心肺复苏术（S-CPR），主动按压复苏术（ACD-CPR）,带有增强型体外反搏的标准复苏术（SE-CPR）和新型复苏术AEI-CPR。结果-前向血流(Forward Flow, FF)以及冠脉灌注压(Coronary Perfusion Pressure, CPP)是评价血流动力学效果的重要参数。S-CPR产生FF 1.12L/min,CPP 18.33mmHg；ACD-CPR产生FF 1.178L/min,CPP 19.29mmHg;SE-CPR产生FF 5.177L/min,CPP 13.89mmHg; AEI-CPR产生FF为5.64mmHg，CPP 22.27mmHg。结论：带有增强型体外反搏的复苏术可产生显著提高的前向血流，AEI-CPR的血流动力学效果显著提高。

The Hemodynamic Effects of AEI-CPR: Study in A Computer Model

Background-This study was done to elucidate mechanism of the new cardiopulmonary resuscitation (CPR) technique in the computer model. The new CPR was called Active Compression-Decompression CPR with Enhanced External Counterpulsation and the Inspiratory Impedance Threshold Valve (AEI-CPR); En-hanced External Counterpulsation (EECP) was the lower limbs compression technique that enhances the blood reflowing during the recoil phase of chest compression. And the study was to compare AEI-CPR with Standard CPR, Active Compression-Decompression CPR (ACD CPR) in the same computer model. Methods and Results- Mathematical model describing hemodynamics of adult human circulation during cardiac arrest and CPR were created and exercised by Matlab/Simulink. The parameters of the models are assumed according to the normal human anatomy and physiology. Standard CPR generates forward flow 1.12 L/min and Coronary Perfusion Pressure (CPP) 18.33mm Hg; ACD-CPR generates forward flow 1.178 L/min and CPP 19.29mm Hg. S-CPR with EECP generates forward flow 5.177 L/min and CPP 13.89mm Hg; AEI-CPR generates forward flow 5.64mm Hg and CPP 22.27mmHg.AEI-CPR can get better hemody-namic effects. Conclusions-EECP, Combined with the conventional CPR can get better hemodynamic ef-fects. The computer model can give some instructions to the animal and clinical experiments.