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A structurally abnormal insulin causing human diabetes. |
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| Authors: | H Tager B Given D Baldwin M Mako J Markese A Rubenstein J Olefsky M Kobayashi O Kolterman R Poucher |
| Abstract: | Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain. |
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