Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis |
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| Authors: | J Ostermann A L Horwich W Neupert F U Hartl |
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| Institution: | Institut für Physiologische Chemie der Universit?t München, FRG. |
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| Abstract: | Mitochondrial heat-shock protein hsp60 functions in the folding of proteins imported into mitochondria. Folding occurs at the surface of hsp60 in an ATP-mediated reaction, followed by release of the bound polypeptides. We propose that hsp60 catalyses protein folding. |
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