| 胃癌中Hp感染和Stat3活化的临床病理意义及其对预后的影响 |
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| 引用本文： | 李秀明,从丽,张微,李一鑫,张楠,赵瑾,陶林,李锋,张文杰.胃癌中Hp感染和Stat3活化的临床病理意义及其对预后的影响[J].石河子大学学报,2014(2):187-192. |
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| 作者姓名： | 李秀明 从丽 张微 李一鑫 张楠 赵瑾 陶林 李锋 张文杰 |
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| 作者单位： | 石河子大学医学院病理系/新疆地方与民族高发病教育部重点实验室,石河子832002 |
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| 基金项目： | 新疆兵团研究生科研创新计划项目（XJGR12013066）,石河子大学绿洲学者基金（LZXZ201023） |
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| 摘 要： |
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| 关 键 词： | 癌 H pylori Stat3 实时荧光定量PCR 癌转移 预后 |
Clinicopathological and Prognostic Significance of H. pylori Infection and Constitutive Activation of Stat3 in Patients with Gastric Cancer |
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| LI Xiuming,CONG Li,ZHANG Wei,LI Yixing,ZHANG Nan,ZHAO Jin,TAO Lin,LI Feng,ZHANG Wenjie.Clinicopathological and Prognostic Significance of H. pylori Infection and Constitutive Activation of Stat3 in Patients with Gastric Cancer[J].Journal of Shihezi University(Natural Science),2014(2):187-192. |
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| Authors: | LI Xiuming CONG Li ZHANG Wei LI Yixing ZHANG Nan ZHAO Jin TAO Lin LI Feng ZHANG Wenjie |
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| Institution: | (Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Pathology,School of Medicine,Shihezi University, Shihezi 832002, China) |
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| Abstract: | To investigate the clinical significance and impact of Helicobacter pylori （H. pylori） infection and the levels of activated Stat3 （p-Stat3） on the pathogenesis, progression, and prognosis in patients with gastric cancer.Relative infection of H. pylori was examined in 80 cases of gastric cancer tissues （test group） and 50 cases of adjacent non-cancerous tissues （control group） using real-time PCR.Immunohistochemistry （IHC） was used to test the levels of p-Stat3 in above tissues.The correlations between H.pylori infection and activated p-Stat3 were analyzed versus clinicopathological parameters and patients′survival, respectively.The results showed that （1） The relative infection of H.pylori and the levels of active p-Stat3 in gastric cancer tissues were significantly higher than those in adjacent non-cancerous tissues, respectively （both P〈0.05）. （2） The relative infection of H.pylori and the levels of active p-Stat3 had no significant correlations with patients′age,gender and tumor differentiation,respectively （P〉0.05）;The relative infection of H.pylori showed positive correlations with tumor infiltration depth, lymph node metastasis and TNM stages, respectively （P〈0.05）,but not with the presence of distant metastasis （P〉0.05）;p-Stat3 levels showed significant differences among tumor infiltration depth, the presence of distant metastasis and TNM stages, respectively （P〈0.05）,but exhibited no association with lymph node metastasis （P〉0.05）.Furthermore,a positive correlation was observed between the H.pylori infection and the active p-Stat3 level in gastric cancer tissues. （3） Kaplan-Meier survival analyses indicated that both the H.pylori infection and the p-Stat3 level were negatively correlated with the total survival of gastric cancer patients,i.e.,the higher the magnitude of H.pylori infection or the higher the levels of p-Stat3,the lower the total survival,respectively （P〈0.05）.H.pylori infection is correlated with activated status |
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| Keywords: | Gastric cancer H pylori Stat3 Real-Time quantitative PCR Metastasis prognosis |
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