| 红花黄色素缓释骨架片的研制及其体外释放度的研究 |
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| 引用本文： | 刘中垒,李国玉,谭勇,史彩虹,刘金荣,王金辉.红花黄色素缓释骨架片的研制及其体外释放度的研究[J].石河子大学学报,2009,27(3):328-333. |
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| 作者姓名： | 刘中垒 李国玉 谭勇 史彩虹 刘金荣 王金辉 |
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| 作者单位： | 刘中垒,李国玉,谭勇,刘金荣,LIU Zhonglei,LI Guoyu,TAN Yong,LIU Jinrong(石河子大学药学院,石河子,832002);史彩虹,SHI Caihong(沈阳药科大学中药学院,沈阳,110016);王金辉,WANG Jinhui(石河子大学药学院,石河子,832002;沈阳药科大学中药学院,沈阳,110016;新疆特种植物药资源省部共建重点实验室,石河子,832002)
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| 摘 要： | 制备红花黄色素缓释骨架片,研究其体外药物释放的主要影响因素及其释药机理。以羟丙基甲基纤维素（HPMC）和盐酸壳聚糖为主要骨架材料,采用湿制粒法制备红花黄色素缓释骨架片,并研究HPMC和盐酸壳聚糖含量、片重、片剂硬度、释放介质的pH值和转速等因素对其药物释放性能的影响。最佳制剂工艺条件为HPMC含量（30%）、盐酸壳聚糖含量（3%）、片重（450mg）、片剂硬度（8~10kg）;HPMC和盐酸壳聚糖的含量对药物释放行为影响较大;片重、片剂硬度、溶出介质的pH值和转速对药物释放行为影响较小。按最佳制剂工艺条件制备的红花黄色素缓释骨架片体外药物释放机制为符合R itger-Peppas释药模型的Non-F ick扩散,能维持药物在24h内缓慢释放。
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| 关 键 词： | 红花黄色素 缓释片 骨架片 释药机制 |
The Preparation of Safflower Yellow Sustained-release Matrix Tablets and Their Drug Release in Vitro |
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| LIU Zhonglei,LI Guoyu,TAN Yong,SHI Caihong,LIU Jinrong,WANG Jinhui,.The Preparation of Safflower Yellow Sustained-release Matrix Tablets and Their Drug Release in Vitro[J].Journal of Shihezi University(Natural Science),2009,27(3):328-333. |
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| Authors: | LIU Zhonglei LI Guoyu TAN Yong SHI Caihong LIU Jinrong WANG Jinhui |
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| Institution: | 1 College of Pharmacy;Shihezi University;Shihezi 83200;China;2 School of Traditional Chinese Materica Medica;Shenyang Pharmaceutical University;Shenyang 110016;3 Key Laboratory of Phytomedicine Resources & Modernization of TCM;Shihezi 832002;China |
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| Abstract: | To prepare the safflower yellow sustained-release matrix tablets and to study their drug-release main influencing factors and mechanism in vitro.The safflower yellow sustained-release matrix tablets were made of HPMC and chitosan hydrochloride both which were used for gel-matrix material by means of wet granulation,and were investigated on their drug-release main influencing factors such as the content of HPMC and chitosan hydrochloride,tablet weight,tablet hardness,pH value in dissolution medium,rotational... |
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| Keywords: | safflower yellow sustained-release matrix tablets drug release mechanism |
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