丙型肝炎病毒感染与口腔扁平苔藓相关性的Meta分析

目的 对丙型肝炎病毒感染与口腔扁平苔藓之间的关系进行系统评价。方法计算机检索Cochrane图书馆2007年第3期MEDLINE、Pubmed、Highwire、CBM、CNKI，检索时间从1992年-2007年。纳入所有研究丙型肝炎病毒与口腔扁平苔藓相关性的配对与非配对的病例对照研究。由2名评价者共同评价纳入研究质量。采用RevMan4．2软件对数据进行Meta分析，估计其OR值和95％CI。结果共纳入11个研究，包括口腔扁平苔藓患者754例，正常对照1973例。其中以正常人为对照研究的6例。以除扁平苔藓以外的口腔粘膜病为对照的4例，以两者为对照研究的1例，按照对照来源进行亚组分析，结果表明口腔扁平苔藓组丙型肝炎病毒感染率明显高出对照组，且结果有显著差异OR合并=5．70（95％CI3．64，8．94），OR合并=5．23（95％CI3．78，8．09）]。结论研究结果显示，丙型肝炎病毒感染与口腔扁平苔藓有关，口腔扁平苔藓患者有更高的丙型肝炎病毒感染率。但由于纳入研究存在选择性偏倚、混杂性偏倚以及诊断性偏倚的中、高度可能性，可能影响了研究结果。

Meta-analysis of the relationship between hepatitis C virus infection and oral lichen planus

Objective： To assesse the relationship between hepatitis C virus（HCV） infection and oral lichen Planus（OLP） by recta-analysis method. Methods： We searthed the The Cochrane Library （Issue 3, 2007）, MEDLINE,Pubmed,Highwire,CBM and CNKI （range from 1992 to 2007）.The search was conducted in November 2007. The case-control studies on the relativity between HCV infection and OLP were collected. The quality of included case studies was evaluated independently by two reviewers.RevMan 4.2 software was used for analyze and estimate its OR valute and 95%CI. Results： In total, 11 case-control studies were included, involving 754 OLP patients and 1973 healthy controls. Among the total, 6 studies selected the health adults as controls,4 studies selected the non OLP patients with oral mucosa diseases as controls, and 1 study selected the health adults and Non OLP patients as controls.Compared with the healthy adults and the non OLP patients,the infection ratio of Hepatitis C Virus in OLP patients showed significantly higher levels （OR = 5.7, 95%CI 3.64 to 8.94,OR = 5.23, 95%CI 3.78 to 8.09. Conclusion： The evidence currently available shows that the HCV infection may be relevant to OLP. However, these results could be affected by the high risk of selection, confounding and diagnostic bias of included studies.