网络药理学在中药复杂作用模式研究中的应用进展

中药多层次、多系统的复杂作用模式的表征一直是中药现代研究的一个关键问题。网络药理学借助计算机技术、系统生物学、多向药理学等多学科的交叉融合,形成了以网络靶标为核心的技术体系,实现了成分-靶标-疾病的分子网络构建,在中药现代研究中显示了巨大的潜力。对近年来网络药理学在网络构建及分析技术、中药复杂作用模式研究进展、未来发展趋势等方面进行了综述,以期为传统中药科学内涵的深入阐释提供新的思路。

Chemical constituents of flowers of Fritillariae Thunbergii Miq.

Chemical constituents of the ethyl acetate part from 95% ethanol extract of flowers of Fritillariae Thunbergii Miq.were studied herein. Positive silica gel column chromatography, reverse C18 medium pressure column chromatography, and semi-preparative high performance liquid chromatography were used for the separation and purification. The structures of the obtained compounds were identified using NMR and MS. From the ethyl acetate extract of the flowers of Fritillariae Thunbergii Miq., eight compounds were isolated and identified, which included n-nonacosane(1), linoleic acid(2), palmitic acid(3), trans-ferulic acid(4), trans-p-hydroxy cinnamic acid(5), caffeic acid(6), esculetin(7), and Z-p-hydroxyl cinnamic acid (8). To the best of our knowledge, compound 1~8 are all isolated from this plant for the first time.