黄芪不同溶剂提取物抑制前列腺增生的研究

通过比较黄芪不同溶剂提取物对前列腺增生的抑制作用，为寻找黄芪抗前列腺增生作用的活性成分奠定基础。比较了3种不同浓度乙醇提取物及水提取物对前列腺增生模型大鼠前列腺系数大小、离体膀胱逼尿肌的收缩强度、血清睾酮和二氢睾酮浓度的影响。结果表明，黄芪4种溶剂提取物组对模型大鼠的前列腺系数均具有较好的抑制作用（P<0.01），95%乙醇提取物作用更明显，与其他3组相比具有显著差异（P＜0.05）；4种提取物还能增加模型大鼠膀胱逼尿肌条收缩强度，降低模型大鼠血清睾酮和二氢睾酮的浓度，其中95%乙醇提取物组作用更强，与其他提取物组比较有显著的差异（P<0.01）。黄芪不同溶剂提取物对大鼠前列腺增生具有较好的抑制作用，95%乙醇提取物作用更好，机理可能与降低血清中睾酮和二氢睾酮的浓度有关，活性成分可能是毛蕊异黄酮为主的黄酮苷元成分。

Study on the inhibitory effects of different solvent extracts from Astragali Radix on prostatic hyperplasia

The inhibitory effects of different solvent extracts from Astragali Radix on benign prostatic hyperplasiawere compared in this paper so as to lay a foundation for the search of active ingredients of Astragali Radix against prostatic hyperplasia. The effects of three different concentrations of ethanol extracts and water extracts on the prostate coefficient of prostate hyperplasia model rats, the contraction strength of isolated bladder detrusor muscle, serum testosterone and dihydrotestosterone concentrations were compared. Results showed that the four solvent extracts of Astragali Radix had a good inhibitory effect on the prostate coefficient of model rats (P<0.01). The effect of 95% ethanol extract was more obvious, and there was a significant difference when compared with other three groups(P<0.05); The four extracts also increased the contractile strength of the bladder detrusor strips in model rats and reduced the serum testosterone and dihydrotestosterone concentrations in the model rats. The 95% ethanol extract group was even more effective than other extract groups, and there was a significant difference when compared with other three extract groups (P<0.01). Thus, it can be concluded, different solvent extracts of Astragali Radix have good inhibition on BPH in rats, and the effect of 95% ethanol extract is better. The mechanism may be related to decreasing the concentrations of testosterone and dihydrotestosterone in serum. The active ingredient may be flavonoid aglycone, which is mainly composed of calycosin.