| 一种烯丙位氧化方法的改进 |
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| 引用本文： | 葛永昌,杨庆雄.一种烯丙位氧化方法的改进[J].贵州师范大学学报(自然科学版),2009,27(3):119-121. |
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| 作者姓名： | 葛永昌 杨庆雄 |
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| 作者单位： | 1. 贵州大学精细化工研究开发中心,贵州,贵阳,550025
2. 贵州师范大学生命科学学院,贵阳,550001 |
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| 摘 要： | 以N-羟基-琥珀酰亚胺为促进剂,铬酐为氧化剂,在含水丙酮体系中对去氢表雄酮进行烯丙位氧化,合成了7-氧代-去氢表雄酮。降低了铬酐的用量,提高了反应得率。该方法也可以应用于其他△5-甾体化合物的烯丙位氧化中。
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| 关 键 词： | 烯丙位氧化 N-羟基-琥珀酰亚胺 7-氧代-去氢表雄酮 |
An improved method for allylic oxidation reaction |
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| GE Yong-chang,YANG Qing-xiong.An improved method for allylic oxidation reaction[J].Journal of Guizhou Normal University(Natural Sciences),2009,27(3):119-121. |
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| Authors: | GE Yong-chang YANG Qing-xiong |
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| Institution: | 1.Research and Development Center for Fine Chemicals;Guizhou University;Guiyang;Guizhou 550025;China;2.School of life Sciences;Guizhou Normal University;Guiyang 550001;China |
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| Abstract: | 7-oxo-dehydroepiandrosterone was synthesized by the allylic oxidation of dehydroepiandrosterone in the acetone-water medium by CrO3 and N-hydroxyl-succinimide.Similar method was applied to the preparation of several 7-oxo steroidal compounds from the allylic oxidation of △5-steroidal compounds,and good results were obtained. |
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| Keywords: | allylic oxidation N-hydroxyl-succinimide 7-oxo-dehydroepiandrosterone |
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