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豫南地区汉族人群类风湿关节炎患者IL-18基因启动子-607C/A多态性检测
引用本文:宋新强,易朝辉,汪学群,刘荣坤,张斯荷.豫南地区汉族人群类风湿关节炎患者IL-18基因启动子-607C/A多态性检测[J].信阳师范学院学报(自然科学版),2012,25(3):329-332.
作者姓名:宋新强  易朝辉  汪学群  刘荣坤  张斯荷
作者单位:1. 信阳师范学院生命科学学院,河南信阳,464000
2. 信阳职业技术学院,河南信阳,464000
3. 信阳市中心医院风湿免疫科,河南信阳,464000
基金项目:国家自然科学基金青年基金资助项目(30801010);河南省科技计划项目(2009A180017);信阳师范学院青年科研基金项目(20080207)
摘    要:采用序列特异性引物的聚合酶链反应技术(PCR-SSP)分析110例类风湿关节炎(RA)患者和100例健康体检者的IL-18基因启动子在-607位点的单个核苷酸多态性,检测豫南地区汉族人群白细胞介素18(interleukin-18,IL-18)基因启动子单个核苷酸多态性与类风湿性关节炎(rheumatoid arthritis,RA)的发生是否存在关联.结果表明,RA患者组与健康对照组在IL-18基因-607位点的等位基因频率的分布及基因型频率的分布比较差异均有统计学意义(χ2=8.668、4.225,P<0.05),抗CCP抗体阳性组和阴性组在IL-18基因-607位点的基因型频率分布差异没有统计意义(χ2=0.941,P>0.05),说明IL-18基因启动子-607位点的多态性与RA患者类风湿因子存在关联.

关 键 词:白细胞介素-18(IL-18)  类风湿性关节炎  基因多态性

Detection of IL-18 Gene Promoter-607 C/A Polymorphisms in Han Population with Rheumatoid Arthritis in the South of Henan Province
SONG Xin-qiang , YI Zhao-hui , WANG Xue-qun , LIU Rong-kun , ZHANG Si-he.Detection of IL-18 Gene Promoter-607 C/A Polymorphisms in Han Population with Rheumatoid Arthritis in the South of Henan Province[J].Journal of Xinyang Teachers College(Natural Science Edition),2012,25(3):329-332.
Authors:SONG Xin-qiang  YI Zhao-hui  WANG Xue-qun  LIU Rong-kun  ZHANG Si-he
Institution:1(1.College of Life Sciences,Xinyang Normal University,Xinyang 464000,China; 2.Xinyang Vocational and Technical College,Xinyang 464000,China; 3.Department of Rheumatism and Immunology,The Central Hospital of Xinyang,Xinyang 464000,China)
Abstract:Using polymerase chain reaction with sequence specific primers method(PCR-SSP),the single nucleotide polymorphisms of the promoter region of IL-18 gene at position-607 was detected in 110 RA patients and 100 controls.Results showed that there was significant difference in the distributions of the IL-18-607 genotype frequencies and allele frequency in RA patients compared with those of controls(χ2=8.668、4.225,P < 0.05).On the distribution of IL-18-607 genotypic frequencies,no significant difference was observed between positive group and negative group of the anti-CCP antibody(χ2 = 0.941,P > 0.05) and the polymorphism of IL-18 gene at position-607 might show correlation with RF in RA patients.
Keywords:interleukin-18(IL-18)  rheumatoid arthritis  18  gene polymorphism
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