| 酿酒酵母中心代谢网络动力学建模 |
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| 引用本文： | 陈洁,林保宏.酿酒酵母中心代谢网络动力学建模[J].信阳师范学院学报(自然科学版),2014(4):483-489. |
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| 作者姓名： | 陈洁 林保宏 |
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| 作者单位： | 1. 上海交通大学 系统生物医学研究院，系统生物医学教育部重点实验室，上海200240
2. 国立台湾科技大学 电子工程学系，台湾 台北10607 |
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| 基金项目： | 国家重点基础研究发展计划(973)资助项目 |
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| 摘 要： | 以酿酒酵母中心代谢网络为研究对象进行代谢网络动力学模拟,将酶反应速率方程改写成普适的形式,模拟了以葡萄糖为碳源的一次生长代谢状态,计算得到了代谢网络达到稳态的代谢流分布以及全部代谢物浓度随时间变化的情况,并将模拟得到的代谢流分布与实验结果进行了比较,结果具有一致性.
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| 关 键 词： | 代谢网络 动力学建模 酿酒酵母 |
Kinetic Modeling of Saccharomyces cerevisiae Central Metabolic Network |
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| Chen Jie,Lin Baohong.Kinetic Modeling of Saccharomyces cerevisiae Central Metabolic Network[J].Journal of Xinyang Teachers College(Natural Science Edition),2014(4):483-489. |
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| Authors: | Chen Jie Lin Baohong |
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| Institution: | Chen Jie;Lin Baohong;Shanghai Center for Systems Biomedicine,Key Laboratory of Systems Biomedicine,Ministry of Education,Shanghai Jiao Tong University;Department of Electronic and Computer Engineering,National Taiwan University of Science and Technology; |
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| Abstract: | The Saccharomyces cerevisiae central metabolism of exponential growth via generic enzymatic rate equation was simulated. Metabolic fluxes and metabolite concentrations of Saccharomyces cerevisiae central metabolism were calculated over time. The calculated results were in good agreement with the experiments in literature. |
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| Keywords: | metabolic network kinetic modeling Saccharomyces cerevisiae |
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