| Wnt/β-catenin信号途径在DDR和氧化应激中的作用 |
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| 作者单位： | ;1.信阳师范学院生命科学学院;2.信阳师范学院大别山农业生物资源保护与利用研究院 |
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| 摘 要： | Wnt/β-catenin信号途径在调控基因表达与DNA损伤反应(DNA damage response,DDR)中具有重要作用.氧化应激是导致DNA损伤的主要原因,且可以影响Wnt信号.首先总结了Wnt/β-catenin信号途径和DDR,然后综述了Wnt/β-catenin信号途径在DDR和氧化应激中的作用及分子机制,以期为DNA修复缺陷性肿瘤提供更有效的治疗策略.
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| 关 键 词： | Wnt/β-catenin信号途径 DNA损伤反应 氧化应激 |
Wnt/β-catenin Pathway in DDR and Oxidative Stress |
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| Institution: | ,College of Life Sciences,Xinyang Normal University,Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains,Xinyang Normal University |
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| Abstract: | Wnt/β-catenin signaling pathway has important functions in regulating gene expression and DNA damage response( DDR). Oxidative stress,which is responsible for majority of DNA lesions,affects Wnt signaling. Firstly,the Wnt/β-catenin signaling pathway and DDR were summarized,then the role and mechanism of Wnt/β-catenin signaling in DDR and oxidative stress were reviewed,in the hope of providing more effective strategies for treatment of cancer cells with deficient DNA repair capacity. |
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| Keywords: | Wnt/β-catenin signaling pathway DNA damage response oxidative stress |
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