| 全缘叶蓝刺头化学成分研究 |
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| 引用本文： | 裴迪,木尼热·艾兰汗,波拉提·马卡比力,张涛,邹忠梅.全缘叶蓝刺头化学成分研究[J].信阳师范学院学报(自然科学版),2018(1):104-108. |
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| 作者姓名： | 裴迪 木尼热·艾兰汗 波拉提·马卡比力 张涛 邹忠梅 |
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| 作者单位： | 新疆大学生命科学与技术学院;新疆师范大学生命科学学院;新疆维吾尔自治区药物研究所自治区哈萨克医药研究所;中国医学科学院北京协和医学院药用植物研究所; |
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| 摘 要： | 研究了全缘叶蓝刺头(Echinops integrifolius Kar.et Kir.)根的化学成分.采用反复硅胶柱色谱、Sephadex LH-20葡聚糖凝胶柱色谱、半制备HPLC、制备薄层色谱及重结晶等技术手段进行分离纯化,通过理化性质、核磁共振波谱及质谱数据鉴定结构.结果从全缘叶蓝刺头根乙醇提取物的石油醚萃取部位及乙酸乙酯萃取部位分离得到7个化合物,分别鉴定为大黄素甲醚(1)、(+)-11α,13-二氢去氢木香内酯(2)、豆甾醇(3)、7-羟基香豆素(4)、东莨菪素(5)、对羟基苯甲酸(6)和茵芋苷(7),其中化合物6是首次从该植物中分离得到,化合物1、2、5和7是首次从蓝刺头属中分离得到.
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| 关 键 词： | 全缘叶蓝刺头 分离纯化 结构鉴定 化学成分 |
Studies on Chemical Constituents of Echinops integrifolius Kar. et Kir. |
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| Institution: | ,College of Life Science and Technology,Xinjiang University,College of Life Science,Xinjang Nomal University,Xinjiang Institute of Kazak Medicine,Xinjiang Institute of Materia Medica,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College |
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| Abstract: | The chemical constituents of the roots of Echinops integrifolius were studied.The compounds were isolated and purified by silica gel column chromatography,Sephadex LH-20,semi-HPLC,preparative thin layer chromatography and recrystallization.The structures were identified by physicochemical properties and spectral data.Seven compounds were isolated from the roots of E.integrifolius and identified as physcion(1),(+)-11α,13-dihydrodehydrocostuslactone(2),stigmasterol(3),7-hydroxy-counmarin(4),scopoletin(5),p-hydroxybenzoic acid(6)and skimmin(7),respectively,among which compound 6 was isolated for the first time from this plant and compounds 1,2,5 and 7 were isolated for the first time fromEchinops genus. |
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| Keywords: | Echinops integrifolius Kar et Kir isolation and purification structure identification chemical constituents |
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