ACE2、AT2R、eNOS基因与原发性高血压相关性研究

原发性高血压（EH）是一种由遗传因素和环境因素共同作用导致的严重危害人类健康的心血管疾病。高血压疾病基因的研究有助于高血压发病机制的探讨,对其早期预防和及时治疗具有十分重要的理论意义和巨大的临床应用前景。至今研究者们已经发现有一百多种基因与原发性高血压的发病有关,特别是内皮型一氧化氮合酶（eNOS）更是研究的热点。已经确定肾素血管紧张素系统（RAS）在调控心血管功能时发挥重要作用,最近又在该系统中新发现了两个成员——血管紧张素转换酶2（ACE2）和血管紧张素Ⅱ2型受体（AT2R）,但是对其研究报道较少。文章分别从eNOS,ACE2和AT2R的生物学特性和作用机制的情况,探讨其与原发性高血压的相关性。

Association between ACE2, AT2R and eNOS Gene with Essential Hypertension

Essential hypertension （EH） is a common human disease believed to result from the interplay of multiple genetic and environmental determinants. Hypertension is one of the most important risk factors for cardiovascular diseases. Identifying hypertension susceptibility genes will help understanding the pathophysiology of the disease and for hypertension prevention and control. In the present study, researchers have found that more than 100 genes were associated with EH, especially, endothelial nitric oxide synthase （eNOS）. The reninangiotensin system （RAS） plays an important role in cardiovascular regulation. Recently, two new genes, angiotensin - converting enzyme 2 （ACE2） and angiotensin Ⅱ type 2 receptor gene （ AT2R）, had been found. Although the relationships between the polymorphisms of RAS genes and hypertension have been extensively studied, there are few reports on the association between the human ACE2 and AT2R gene and EH. The biological activity and mechanisms of eNOS , ACE2 and AT2R , respectively, have drawn considerable attention in this context , to assess the genes as risk factors for EH.