| 双氢杨梅树皮素对链脲霉素所致糖尿病大鼠的降糖作用 |
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| 引用本文： | 钟正贤,覃洁萍,陈学芬,周桂芬.双氢杨梅树皮素对链脲霉素所致糖尿病大鼠的降糖作用[J].广西科学,2000,7(3):203-205. |
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| 作者姓名： | 钟正贤 覃洁萍 陈学芬 周桂芬 |
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| 作者单位： | 1. 广西中医药研究所,南宁东葛路20-1号,530022
2. Pharmacy Department of Guangxi College of Chinese Traditional Medicine,530001 |
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| 基金项目： | 广西科学基金，9736008， |
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| 摘 要： | 用链脲霉素（ＳＴＺ）所致的大鼠糖尿病作模型，给予双氢杨梅树皮素（ＡＰ）连续治疗３０ｄ，探讨ＡＰ的降糖作用机理。结果表明：ＡＰ能使ＳＴＸ糖尿病大鼠的高血糖反应减轻，增加血清中ＳＯＤ－ｃｕ．ｚｎ活性，降低ＭＤＡ含量，对血脂中的甘油三酯（ＴＧ）水平有降低趋势；可提高血清中胰岛素水平。组织学研究可见ＡＰ组大鼠胰腺组织中的胰岛数目较模型组增多，淋巴细胞浸减少，炎症反应减轻。其作用机理可能是通过ＡＰ的抗氧化作
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| 关 键 词： | 双氢杨梅树皮素 链脲霉素 糖尿病 降糖作用 |
| 收稿时间： | 2000/3/2 0:00:00 |
| 修稿时间： | 2000/5/11 0:00:00 |
Hypoglycemic Effect of Ampelopsin on Diabetic Rats Induced by Steptozotocin |
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| Zhong Zhengxian,Qin Jieping,Chen Xuefen and Zhou Guifen.Hypoglycemic Effect of Ampelopsin on Diabetic Rats Induced by Steptozotocin[J].Guangxi Sciences,2000,7(3):203-205. |
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| Authors: | Zhong Zhengxian Qin Jieping Chen Xuefen and Zhou Guifen |
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| Institution: | Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20-1 Donggelu, Nanning, Guangxi, 530022, China,Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20-1 Donggelu, Nanning, Guangxi, 530022, China,Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20-1 Donggelu, Nanning, Guangxi, 530022, China and Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20-1 Donggelu, Nanning, Guangxi, 530022, China |
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| Abstract: | For studying the mechanism of ampelopsin hypoglycemic effect,fifty SD strain male rats with diabetic models induced by steptozotocin(STZ) were treated with ampelopsin(AP) for 30 days.The results showed that AP could lighten hyperglycemic reaction, increase the SOD-cu.zn activity and decrease the MDA contents; triglyceride (TG) in blood-lipid had lowering tendency and raised insulin levels in serum. Histological examination showed that pancreatic island number in pancreas in AP groups increased in compared with the model group, reducing lymphocyte infiltration and lightening inflammatory. It's mechanism might be of lightening the β-cell injuring of pancreatic island induced by STZ or promoting the reparation of injured β-cells, and enhancing the secreted function of pancreatic island cells through the anti-oxidation of AP,thus lowering blood sugar level in diabetic rats. |
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| Keywords: | ampelopsin hypoglycemic lipid lowering anti oxidation animal experiment |
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