| 褪黑激素对小鼠免疫功能的影响 |
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| 引用本文： | 曾雪瑜,彭树勋.褪黑激素对小鼠免疫功能的影响[J].广西科学,1994,1(3):41-42,79. |
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| 作者姓名： | 曾雪瑜 彭树勋 |
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| 作者单位： | 香港大学医学院生理系，广西中医药研究所 |
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| 摘 要： | 采用３Ｈ－ＴｄＲ掺入法和溶血素测定法观察褪黑激素（Ｍｔ）对刀豆素（ＣｏｎＡ）诱导小鼠脾淋巴细胞增殖和半数溶血值（ＨＣ５０）的影响。结果表明，Ｍｔ于光周期傍晚腹腔注射０．０１、０．０５、０．１ｍｇ／ｋｇ能明显促进ＣｏｎＡ诱导的小鼠脾淋巴细胞增殖，提高可的松抑制的脾淋巴细胞增殖及环磷酰胺抑制的半数溶血值。提示Ｍｔ具有免疫增强作用和对抗应激引起的免疫抑制作用，在临床医学上具有广阔应用前景。
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| 关 键 词： | 褪黑激素，淋巴细胞增殖，半数溶血值（HC＿（50）） |
| 收稿时间： | 1994/5/25 0:00:00 |
| 修稿时间： | 1994/8/11 0:00:00 |
Effect of Melatonin on Immune Function in Mice |
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| Zeng Xueyu and Pang S. F..Effect of Melatonin on Immune Function in Mice[J].Guangxi Sciences,1994,1(3):41-42,79. |
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| Authors: | Zeng Xueyu and Pang S F |
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| Institution: | Faculty of Medicine, University of Hong Kong, Sassoon Road, Hong Kong and Faculty of Medicine, University of Hong Kong, Sassoon Road, Hong Kong |
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| Abstract: | The effects of proliferative responses of melatonin (Mt) on splenocytes stimulated by Con A and HC50 value in mice are studied using 3H-TdR infiltration and hemelysin mensuration. The results show that in medium light (ML), Intraperitoneal (ip) 0. 01,0. 05, 0. 1mg/kg Mt can significantly facilitate prolifera tive responses of splenocyted stimulated by con A in normal mice and, can enchance the proliferation of splenocytes inhibited by cortisone and HC50 value inhibited by cyclophosphamide. The results indicate that Mt possessed potential immunity and anti-tress function. |
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| Keywords: | melatonin proliferation of splenocytes HC_(50)value |
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