| 维生素K3对安定血药浓度及药理作用的影响 |
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| 引用本文： | 钟正贤,周桂芬,莫恃,刘布鸣.维生素K3对安定血药浓度及药理作用的影响[J].广西科学,1997,4(3):217-219,232. |
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| 作者姓名： | 钟正贤 周桂芬 莫恃 刘布鸣 |
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| 作者单位： | [1]广西中医药研究所 [2]广西壮族自治区人民医院麻醉科 |
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| 基金项目： | 广西壮族自治区人民医院麻醉科。 |
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| 摘 要： | 用动物实验研究了维生素Ｋ３对安定血药浓度及药理作用的影响。结果表明，维生素Ｋ３能明显缩短安定血药浓度分布半衰期和消除半衰期，提高安定体内清除率。增加家兔呼吸频率，但不影响麻醉后家兔的心电图、血压和心率。能缩短安定所致小鼠睡眠时间，具有催醒作用。
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| 关 键 词： | 维生素K3 安定 血药浓度 药理作用 |
| 收稿时间： | 1997/5/16 0:00:00 |
| 修稿时间： | 1997/6/25 0:00:00 |
Effect of Vitamin K3 on Blood-drug Concentration and Pharmacologic Action of Diazepam |
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| Zhong Zhengxian,Zhou Guifen,Mo Shi and Liu Buming.Effect of Vitamin K3 on Blood-drug Concentration and Pharmacologic Action of Diazepam[J].Guangxi Sciences,1997,4(3):217-219,232. |
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| Authors: | Zhong Zhengxian Zhou Guifen Mo Shi and Liu Buming |
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| Institution: | Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20 Guchenglu, Nanning, Guangxi, 530022,Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20 Guchenglu, Nanning, Guangxi, 530022,Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20 Guchenglu, Nanning, Guangxi, 530022 and Guangxi Institute of Traditional Medical and Pharmaceutical Sciences, 20 Guchenglu, Nanning, Guangxi, 530022 |
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| Abstract: | The effect of vitamin K 3 on blood drug concentration and pharmacologic action of diazepam was studied by animal experiment.The results showed that vitamin K 3 could markedly shorten distributed half life and eliminate half life,and increase elimination rate of diazepam in body,enhance breathe frequency, but no effect on electrocardiogram,blood pressure and heart rate of rabbits after anaesthesia.Vitamin K 3 can shorten sleep time induced by diazepam in mices,possessing analeptic action. |
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| Keywords: | vitamin K 3 diazepam blood drug concentration pharmacologic action |
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