| 正交试验优化盐酸普鲁卡因合成工艺 |
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| 引用本文： | 寇亮,杨玉宏,林勤,宋颖雪,吕周郎.正交试验优化盐酸普鲁卡因合成工艺[J].西北民族学院学报,2013(3):13-16. |
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| 作者姓名： | 寇亮 杨玉宏 林勤 宋颖雪 吕周郎 |
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| 作者单位： | 西北民族大学化工学院,甘肃兰州730030 |
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| 基金项目： | 西北民族大学本科教学建设项目（12JG-16706625）之阶段性成果. |
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| 摘 要： | 目的：研究盐酸普鲁卡因合成工艺的影响因素，探索盐酸普鲁卡因合成的最佳条件．方法：采用正交试验，考察β-二乙胺基乙醇与对硝基苯甲酸质量之比（A）、催化剂甲酸用量（与对硝基苯甲酸用量的质量百分比）（B）、反应时闻（C）三个因素对盐酸普鲁卡因产率的影响．结果：盐酸普鲁卡因合成的最佳条件为A3B2C3．结论：在此工艺条件下，盐酸普鲁卡因产率为69．74％（以β-二乙胺基乙醇的投料量计算）．
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| 关 键 词： | 盐酸普鲁卡因的合成 工艺优化 正交试验 |
Orthogonal Test Design for Optimization of Synthetic Process of Procaine Hydrochloride |
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| KOU Liang,YANG Yu-hong,LIN Qin,SONG Ying-xue,LV Zhou-lang.Orthogonal Test Design for Optimization of Synthetic Process of Procaine Hydrochloride[J].Journal of Northwest Minorities University(Natural Science ),2013(3):13-16. |
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| Authors: | KOU Liang YANG Yu-hong LIN Qin SONG Ying-xue LV Zhou-lang |
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| Institution: | (Chemical Engineering College of Northwest University for Nationalities, Lanzhou 730030, China) |
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| Abstract: | Objective The influence factors of procaine hydrochloride synthetic process were studied, and the best reaction conditions for sythesis of procaine hydrochloride were explored. Method Three factors affecting on the productivity of procaine hydrochloride： β - diethylamine - ethanol to p - nitrobenzoic acid mass ratio （A）, catalyst formic acid （percentage of the amount of p- nitrobenzoic acid） （B）, the reaction time（C） were investigated by applying orthogonal test. Then, the productivity of procaine hydrochloride was selected as the index to search the best reaction conditions. ResuIts The best reaction condition is A3B2C3. Conclusion In such reaction conditions＇ the yield of procaine hydrochloride can be reached 69.74% （Calculated according to the mass of β - diethylamine - ethanol）. |
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| Keywords: | Synthesis of procaine hydrochloride Process optimization Orthogonal test |
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