| 硝呋太尔合成工艺的优化 |
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| 引用本文： | 尚红艳,陈亚鹏.硝呋太尔合成工艺的优化[J].河北省科学院学报,2011,28(2):58-61. |
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| 作者姓名： | 尚红艳 陈亚鹏 |
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| 作者单位： | 1. 石家庄市中小学生校外综合实践活动基地,河北石家庄,050000
2. 河北化工医药职业技术学院,河北石家庄,050076 |
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| 摘 要： | 对已有硝呋太尔合成工艺进行改进,直接采用市售的甲硫醇钠为原料,与环氧氯丙烷缩合得到甲硫基环氧丙烷。甲硫基环氧丙烷经过肼解、环合、缩合得到硝呋太尔。其中,肼解反应得到的肼解物不经分离直接进行环合反应,硝呋太尔收率比国内外文献报道高10%左右,降低了生产成本,适合工业化生产。
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| 关 键 词： | 硝呋太尔 合成工艺 优化 |
Optimizing the synthetic process of Nifuratel |
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| SHANG Hong-yan,CHEN Ya-peng.Optimizing the synthetic process of Nifuratel[J].Journal of The Hebei Academy of Sciences,2011,28(2):58-61. |
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| Authors: | SHANG Hong-yan CHEN Ya-peng |
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| Institution: | 1.Shijiazhuang Comprehensive Practice Base for Primary & Middle School,Shijiazhuang 05000,China;2.Hebei Chemical & Pharmaceutical Vocational Technology College,Shijiazhuang Hebei 050026,China) |
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| Abstract: | To improve the synthetic process of nifuratel,it used the commercially available 3-methylthio-（1,2-epoxypropane） as raw materials,condensated with PO to obtain Ethylthio-epoxy propane.This compound was then treated according to the known procedures such as hydrazinolysis and cyclization and condensation to form nifuratel.Products of hydrazinolysis reaction cyclizated directly without separation.By improving the synthetic process,the yield of compound nifuratel was exceeding 10% from what was reported.These reduced the cost of production and was suitable for the nifuratel production in factories. |
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| Keywords: | Nifuratel Synthetic process Optimization |
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