| 红树林内生真菌Penicillium sp.生物碱类次级代谢产物研究 |
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| 引用本文： | 张亮,刘艳辉,李新兰,贺良泳,郭志勇,邹坤,汪鋆植.红树林内生真菌Penicillium sp.生物碱类次级代谢产物研究[J].三峡大学学报(自然科学版),2011,33(3):105-108. |
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| 作者姓名： | 张亮 刘艳辉 李新兰 贺良泳 郭志勇 邹坤 汪鋆植 |
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| 作者单位： | 三峡大学化学与生命科学学院,天然产物研究与利用湖北省重点实验室,湖北宜昌,443002 |
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| 基金项目： | 国家自然科学基金资助项目(21002058); 湖北省自然科学基金项目(2009CDB365); 湖北省教育厅项目(Q20091305) |
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| 摘 要： | 7,18-dihydroxy-16,18-dimethyl-9-methoxy-10-phenyl（7,13E,16S,18S,19R）11]cytochala-sa-6（12）13-diene-1,21-dione（1）,7-hydroxy-16-18-dimethyl-10-phenyl11]cytochalasa-6（12）13-diene-1,21-dione（2）和viscumamide（3）3个生物碱类次级代谢产物来自于红树林内生真菌Peni-cillium sp.,通过一维和二维的核磁共振技术确定其结构,药理活性筛选结果表明,化合物1,2,3均对金黄葡萄球菌,和白色链球菌等有不同程度的抑制活性.
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| 关 键 词： | 红树林内生真菌 松胞素 环肽 抗菌活性 |
Alkaloid Metabolites and Their Antimicrobial Activity from Mangrove Endophytic Fungus Penicillium sp. |
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| Zhang Liang,Liu Yanhui,Li Xinlan,He Liangyong,Guo Zhiyong,Zou Kun,Wang Junzhi.Alkaloid Metabolites and Their Antimicrobial Activity from Mangrove Endophytic Fungus Penicillium sp.[J].Journal of China Three Gorges University(Natural Sciences),2011,33(3):105-108. |
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| Authors: | Zhang Liang Liu Yanhui Li Xinlan He Liangyong Guo Zhiyong Zou Kun Wang Junzhi |
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| Institution: | Zhang Liang Liu Yanhui Li Xinlan He Liangyong Guo Zhiyong Zou Kun Wang Junzhi(Hubei Key Laboratory of Natural Products Research & Development,College of Chemistry & Life Science,China Three Gorges Univ.,Yichang 443002,China) |
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| Abstract: | Three alkaloid metabolites,7,18-dihydroxy-16,18-dimethyl-9-methoxy-10-phenyl(7,13E,16S,18S,19R)cytochalasa-6(12)13-diene-1,21-dione(1),7-hydroxy-16-18-dimethyl-10-phenylcytochalasa-6(12)13-diene-1,21-dione(2) and viscumamide(3),were isolated from the mangrove endophytic fungus Penicillium sp.;and their structures were elucidated by NMR and MS spectra.The antimicrobial activity were tested by paper disk method,and the compounds 1-3 displayed inhibition activity to Staphyloccocus aureus,Marilia albican,Bacill... |
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| Keywords: | mangrove endophytic fungus cytochalasin cyclopeptide antimicrobial activity |
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