纳米羟基磷灰石-地塞米松载药体系的制备及体外缓释研究

以CaCl2和Na2HPO4·12H2O为前驱体,在生物安全性能良好的十二烷基硫酸钠(SDS)-聚乙烯吡咯烷酮(PVP)体系中,采用化学沉淀法水热合成得到了纳米羟基磷灰石(nHAP).采用透射电镜、红外光谱、X射线衍射等方法对产品的形貌、晶相、化学组成等进行表征,结果显示:所制备的nHAP为长40～120 nm、宽约30 nm的纳米棒,晶体形貌规则,结晶良好.采用地塞米松作为药物负载对象的研究证实,所合成的nHAP载药性能良好；体外药物缓释实验表明,nHAP-地塞米松载药体系在模拟体液环境中,12h后药物释放率才达到96.8％,具有良好的药物缓释效果.

Synthesis of Nano Hydroxyapatite-Dexamethasone and Its in Vitro Delayed-Release Performance

Using CaCl2 and Na2HPO4·12H2O as starting materials,employing sodium dodecyl sulfate(SDS)-polyvinylpyrrolidone(PVP) soft clusters with good biosecurity as synthetic templates,the nano hydroxyapatite(nHAP) particles were obtained by precipitation hydrothermal method for the first time.The morphology,crystalline phase and composition of the products were characterized by transmission electron microscope,X-ray diffraction and infrared spectrometry.The results showed that the products were nanorods with lengths between 40~120 nm and widths 30 nm.The crystals had uniform morphology and fine crystallinity.Dexamethasone was chosen to test the medicine delayed-release performance of nHAP.Results showed that so-obtained nHAP had good drug loading capacity.In vitro drug delayed-release experiments showed that the release percentage of dexamethasone only reached 96.8% in simulated body fluid for 12 h.This nHAP-dexamethasone complex had obvious medicine delayed-release effect.This method might have important application value in the biomedical engineering field.