| 超氧物歧化酶对糖尿病模型大鼠血液及肾中自由基代谢的影响 |
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| 引用本文： | 王亦根,赵明,张雯,张志敏,杨爱珍,吴国荣,程光宇,魏锦城.超氧物歧化酶对糖尿病模型大鼠血液及肾中自由基代谢的影响[J].南京师大学报,1994(2). |
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| 作者姓名： | 王亦根 赵明 张雯 张志敏 杨爱珍 吴国荣 程光宇 魏锦城 |
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| 作者单位： | 中国人民解放军八一医院，南京师范大学生物系 |
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| 摘 要： | 以链脲菌素诱发ＳＤ大鼠糖尿病模型，发现模型组大鼠血液及肾组织中的Ｔ—ＳＯＤ、Ｃｕ·Ｚｎ—ＳＯＤ水平较正常对照组大鼠下降，而ＬＰＯ、ＭＤＡ含量较正常对照组明显上升（Ｐ＜０．０１）．用不同剂量和不同疗程的纯化Ｃｕ·Ｚｎ－ＳＯＤ肌注治疗，能不同程度升高糖尿病模型大鼠血液及肾组织中Ｔ－ＳＯＤ、Ｃｕ．Ｚｎ－ＳＯＤ含量，降低ＬＰＯ、ＭＤＡ水平，且与ＳＯＤ剂量及疗程的长短是正相关．
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| 关 键 词： | 超氧物歧化酶 糖尿病 自由基 代谢 |
Effect of SOD on the Levels of LPO, MDA and Free Radicals Scavenger in Diabetic Model Rats' Blood and Kidney |
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| Wang Yigen, Zhao Ming, Zhang Wen, Zhang Zhiming, Yang Aizen,Wu Guoroug, Cheng Guaugyu, Wei Jingckeng.Effect of SOD on the Levels of LPO, MDA and Free Radicals Scavenger in Diabetic Model Rats'''' Blood and Kidney[J].Journal of Nanjing Normal University(Natural Science Edition),1994(2). |
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| Authors: | Wang Yigen Zhao Ming Zhang Wen Zhang Zhiming Yang Aizen Wu Guoroug Cheng Guaugyu Wei Jingckeng |
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| Abstract: | The present paper reports that the levels of LPO, MDA are higher than that in normal rats',T-SOD,Cu. Zn-SOD are lower than that in normal rats' (p<0. 01 ). With different doses of SOD and different Periods in treatment, we find that large dose SOD and long period treatment can improve the condition of free radical and it's scavenger in blood and kidney of diabetic model rat. |
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| Keywords: | Superoxide dismutase(SOD) Diabetes mellitus Free radical Metab6lism |
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