| 结核分枝杆菌单克隆抗体与自身抗原组蛋自的免疫交叉反应研究 |
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| 引用本文： | 李琰,陈佩丽,刘文,胡巍,王洪海,庄玉辉,刘为平,朱琪泉.结核分枝杆菌单克隆抗体与自身抗原组蛋自的免疫交叉反应研究[J].复旦学报(自然科学版),1998(4). |
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| 作者姓名： | 李琰 陈佩丽 刘文 胡巍 王洪海 庄玉辉 刘为平 朱琪泉 |
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| 作者单位： | 复旦大学(李琰，陈佩丽，刘文，王洪海，刘为平，朱琪泉)，山东淄博师专(胡巍)，北京解放军309医院(庄玉辉) |
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| 基金项目： | 复旦大学遗传工程国家重点实验室资助 |
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| 摘 要： | WesternBlot实验证实了结核分枝杆菌（Mycobacteriumtuberculosis）H37Ra的单克隆抗体与自身抗原组蛋白发生免疫交叉反应．利用计算机软件对交叉反应的分子生物学基础进行了分析，发现结核分枝杆菌H37Ra的蛋白与组蛋白H1，H2A，H2B，H3，H4各有一个包含3个或4个氨基酸的序列同源区域．
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| 关 键 词： | 结核分枝杆菌 组蛋白 免疫交叉反应 分子模拟 |
Study on Immune Cross-reaction of Mycobacterium Tuberculosis MAb with Self-antigen Histone |
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| Li Yan, Chen Peili, Liu Wen, Hu wei, Wang Honghai.Study on Immune Cross-reaction of Mycobacterium Tuberculosis MAb with Self-antigen Histone[J].Journal of Fudan University(Natural Science),1998(4). |
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| Authors: | Li Yan Chen Peili Liu Wen Hu wei Wang Honghai |
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| Abstract: | Cross-reaction of Mycobacterium tuberculosis H37Ra monoclonal antibody (MAb)with self-antigen histone were demonstrated by western Blotting analysis. The molecular basis of the cross-reaction was investigated by amino acid sequence analysis using computer software. Homologous sequence of three or four amino acids between H37Ra protein and histone were found. |
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| Keywords: | Mycobacteria tuberculosis histone immune cross-reaction molecular mimicry |
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