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| 聚乙二醇-g-聚天冬氨酸(阿霉素)的制备与毒性 | |
| 引用本文： | 曾灿,陈伟,胡建华,孙晓宇.聚乙二醇-g-聚天冬氨酸(阿霉素)的制备与毒性[J].复旦学报(自然科学版),2006,45(6):708-713. |
| 作者姓名： | 曾灿 陈伟 胡建华 孙晓宇 |
| 作者单位： | 1. 同济大学,生命科学与技术学院,上海,200092;复旦大学,高分子科学系,上海,200433 2. 复旦大学,高分子科学系,上海,200433 3. 同济大学,生命科学与技术学院,上海,200092 |
| 基金项目： | 上海市科学技术委员会科研项目(0452nm06503JC14020352nm031) |
| 摘 要： | 聚天冬氨酸侧链修饰得到聚乙二醇接枝聚天冬氨酸(PEG-g-PAsp),将此载体与抗癌药物阿霉素(ADR)反应,透析后得到PEG-g-PAsp(ADR)胶束.药物ADR作为胶束的核,PEG作为外壳,药物的包封率最高可达29.7%.进行的毒性分析表明形成的纳米粒子与纯药物相比,表现出了更高的抗肿瘤活性.从而证明PEG-g-PAsp可以作为一种非常有潜力的药物载体. |
| 关 键 词： | 聚乙二醇 聚天冬氨酸 阿霉素 毒性 |
| 文章编号： | 0427-7104(2006)06-0708-06 |
| 修稿时间： | 2006年5月31日 |
Preparation and Toxicity Study of PEG-g-PAsp(ADR) as Potential Drug Carrier |
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| ZENG Can,CHEN Wei,HU Jian-hua,SUN Xiao-yu.Preparation and Toxicity Study of PEG-g-PAsp(ADR) as Potential Drug Carrier[J].Journal of Fudan University(Natural Science),2006,45(6):708-713. | |
| Authors: | ZENG Can CHEN Wei HU Jian-hua SUN Xiao-yu |
| Abstract: | The side-chain-functionalized polyaspartamides by Poly(ethylene glycol)(PEG) as potential drug carrier was synthesized at first.Adriamycin,a hydrophobic anticancer drug,then,was conjugated to poly(ethylene glycol)-grafted poly(aspartic acid)(PEG-g-PAsp).The final products were found to form micelle through dialysis.The core of the micellar is the hydrophobic adriamycin and the outer shell is hydrophilic PEG.The entrapment efficiency is up to 29.7%.The micelle show less toxicity compared with the pure adriamycin,which demonstrate PEG-g-PAsp can be effectively used in drug delivery systems. |
| Keywords: | Poly(ethylene glycol)(PEG) poly(aspartic acid)(PAsp) adriamycin toxicity |
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