| 慢性不可预知温和应激抑郁小鼠模型的建立 |
| |
| 引用本文： | 张臣颢,张曼芳,谢青莲,成志恒,邹洪,金玫蕾.慢性不可预知温和应激抑郁小鼠模型的建立[J].复旦学报(自然科学版),2011(3):390-393. |
| |
| 作者姓名： | 张臣颢 张曼芳 谢青莲 成志恒 邹洪 金玫蕾 |
| |
| 作者单位： | 中国科学院上海生命科学研究院;上海生物芯片有限公司; |
| |
| 摘 要： | 抑郁症是一种以情绪低落为主要症状的情感性精神障碍.利用慢性不可预知温和应激建立抑郁症小鼠模型，以蔗糖水消耗实验作为抑郁核心症状之一——快感缺乏的检测方法.将4周龄雄性小鼠(C57BL/6)持续6周暴露于一系列轻度应激中，每周检测蔗糖水消耗.应激包括：令小鼠恐惧的气味、噪音、饲养笼倾斜、潮湿的垫料、无垫料的新饲养笼、照明...
|
| 关 键 词： | 慢性不可预知温和应激 抑郁小鼠模型 快感缺乏 |
Establishment of Chronic Unpredictable Mild Stress Mice Model of Depression |
| |
| ZHANG Cheng-hao,ZHANG Man-fang,XIE Qing-lian,CHENG Zhi-heng,ZOU Hong,JIN Mei-lei.Establishment of Chronic Unpredictable Mild Stress Mice Model of Depression[J].Journal of Fudan University(Natural Science),2011(3):390-393. |
| |
| Authors: | ZHANG Cheng-hao ZHANG Man-fang XIE Qing-lian CHENG Zhi-heng ZOU Hong JIN Mei-lei |
| |
| Institution: | ZHANG Cheng-hao1,2,ZHANG Man-fang1,XIE Qing-lian1,CHENG Zhi-heng1,ZOU Hong1,JIN Mei-lei1(1.Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200233,China,2.Shanghai Biochip Co.,Ltd,Shanghai 201203,China) |
| |
| Abstract: | Depression is a chronic mental disorder mainly characterized by depressed mood.A series of chronic unpredictable mild stresses(CUMS) was used to set up a mice model of depression.And sucrose consumption test was adopted to estimate the anhedonia,one of the core symptoms of human depression.Mice(C57BL/6) were exposed to CUMS over 6 weeks,and anhedonia was evaluated by weekly monitoring sucrose intake.The stressors included that soiled cage with aversive odour,noise,cage tilt,damp bedding,illumination overnig... |
| |
| Keywords: | chronic unpredictable mild stress mice depression model anhedonia |
| 本文献已被 CNKI 等数据库收录！ |
|
