| 锌指结构基因HKR1在脑胶质瘤中的表达分析 |
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| 引用本文： | 夏放,祁震宇,戴建凉,顾少华,马良霄,谢毅,毛裕民.锌指结构基因HKR1在脑胶质瘤中的表达分析[J].复旦学报(自然科学版),2000,39(6):692-694. |
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| 作者姓名： | 夏放 祁震宇 戴建凉 顾少华 马良霄 谢毅 毛裕民 |
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| 作者单位： | 1. 复旦大学,生命科学学院,遗传学研究所,上海,200433
2. 苏州医学院,江苏,苏州,215007 |
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| 基金项目： | 上海市现代生物与新药产业发展基金资助项目!(98431912 1) |
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| 摘 要： | 从人胎脑cDNA文库中筛选到2612nt的锌指蛋白HKR1克隆，C端含有10个C2H2锌指结构，N端含有2个KRAB区域，基因芯片的原位杂交检测显示，HKR1基因表达在脑胶质瘤中明显升高，提示该基因可能是一条潜在的肿瘤相关基因。
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| 关 键 词： | 锌指蛋白 脑胶质瘤 基因芯片 表达分析 HKR1基因 |
Expression Analysis of Zinc Finger Protein HKR1 in Neuroglioma |
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| XIA Fang,QI Zhen-yu,DAI Jian-liang,GU Shao-hua,MA Liang-xiao,XIE Yi,MAO Yu-min.Expression Analysis of Zinc Finger Protein HKR1 in Neuroglioma[J].Journal of Fudan University(Natural Science),2000,39(6):692-694. |
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| Authors: | XIA Fang QI Zhen-yu DAI Jian-liang GU Shao-hua MA Liang-xiao XIE Yi MAO Yu-min |
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| Institution: | XIA Fang 1,QI Zhen yu 2,DAI Jian liang 1,GU Shao hua 1,MA Liang xiao 1,XIE Yi 1,MAO Yu min 1 |
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| Abstract: | The cDNA of HKR1 (Human kruppel related gene 1)has been cloned from a human fetal brain cDNA library with 2 612 nt. It is indicated that HKR1 contains 10 highly conserved C 2H 2 type zinc finger motifs at the C terminus and 2 KRAB(Kruppel associated box)domains at the N terminus. It has been found that the expression of HKR1 is higher in neuroglioma than those in normal brain tissue with cDNA microarray and in situ hybridyzation. The results suggest HKR1 might be a putative cancer associated gene. |
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| Keywords: | zinc finger protein neuroglioma microarray |
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