| 醚类汽油添加剂与L-02正常人肝细胞、人血红蛋白的体外作用研究 |
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| 引用本文： | 许丽红,杜慧芳,夏晔,周祖铭.醚类汽油添加剂与L-02正常人肝细胞、人血红蛋白的体外作用研究[J].复旦学报(自然科学版),2002,41(4):395-398. |
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| 作者姓名： | 许丽红 杜慧芳 夏晔 周祖铭 |
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| 作者单位： | 复旦大学环境科学与工程系,上海,200433 |
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| 基金项目： | 国家自然科学基金资助项目 (2 99770 0 5) |
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| 摘 要： | 研究了新型无铅汽油添加剂甲基叔丁基醚（MTBE）、甲基叔戊基醚（TMAE）对正常人肝细胞系L－02的毒性作用，在较高浓度下，MTBE、TAME均对L－02正常人肝细胞的生长有影响，且TAME的毒性作用稍强，另外，用FT－IR法和^1H-NMR法研究了MTBE、TAME与人血红蛋白的体外作用，结果显示，MTBE、TAME与人血红蛋白无明显的直接作用。
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| 关 键 词： | 无铅汽油添加剂 毒性 正常人肝细胞 血红蛋白 |
| 文章编号： | 0427-7104(2002)04-0395-04 |
Study on the Reaction of Unlead Gasoline Additives with L-02 Normal Human Liver Cell and Hemoglobin in Vitro |
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| XU Li hong,DU Hui fang,Xia Ye,Zhou Zu min.Study on the Reaction of Unlead Gasoline Additives with L-02 Normal Human Liver Cell and Hemoglobin in Vitro[J].Journal of Fudan University(Natural Science),2002,41(4):395-398. |
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| Authors: | XU Li hong DU Hui fang Xia Ye Zhou Zu min |
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| Abstract: | Effects of toxicity of new unlead gasoline additives,Methyl tert Butyl Ether (MTBE) and Methyl tert Amyl Ether (TAME),on the growth of L 02 normal human liver cell has been studied. The result shows that both MTBE and TAME prohibit the growth of L 02 in higher concentrations and the effect of TAME is more serious. Interactions between MTBE?TAME and hemoglobin in vitro have also been studied with FT IR spectroscopy and 1H NMR spectroscopy,no obvious interactions have been observed in the experimental condition. |
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| Keywords: | unlead gasoline additives toxicity normal human liver cell hemoglobin |
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