| 提高中药疏水性抗肝炎有效成分锚口山酮总苷溶出度 |
| |
| 引用本文： | 王业清,史可丽,廖志新,纪兰菊,孙洪发.提高中药疏水性抗肝炎有效成分锚口山酮总苷溶出度[J].东南大学学报(自然科学版),2011,41(4):809-814. |
| |
| 作者姓名： | 王业清 史可丽 廖志新 纪兰菊 孙洪发 |
| |
| 作者单位： | 1. 东南大学化学化工学院,南京,211189
2. 中国科学院西北高原生物研究所,西宁,810001 |
| |
| 基金项目： | 国家自然科学基金资助项目(30770233); 青海省重点攻关资助项目(2008-G-136) |
| |
| 摘 要： | 针对某些中药有效成分因水溶性差而引起药物生物利用度低的问题,选取具有抗肝炎活性的花锚总苷为研究对象,运用熔融法或溶剂法分别制备了4种不同载体组成的花锚总苷固体分散体,通过HPLC方法测定溶出度.研究结果表明,聚乙二醇4000、聚乙二醇6000、泊洛沙姆188、聚乙烯基吡咯烷酮k30均能与花锚总苷制备固体分散体,相对于花...
|
| 关 键 词： | 中药有效成分 花锚总苷 固体分散体 溶出度 扫描电子显微镜 |
Improving dissolution of antihepatitis-effective-ingredients total xanth-one glucosides of Halenia elliptica |
| |
| Wang Yeqing,Shi Keli,Liao Zhixin,Ji Lanju,Sun Hongfa.Improving dissolution of antihepatitis-effective-ingredients total xanth-one glucosides of Halenia elliptica[J].Journal of Southeast University(Natural Science Edition),2011,41(4):809-814. |
| |
| Authors: | Wang Yeqing Shi Keli Liao Zhixin Ji Lanju Sun Hongfa |
| |
| Institution: | Wang Yeqing1 Shi Keli1 Liao Zhixin1 Ji Lanju2 Sun Hongfa2(1 School of Chemistry and Chemical Engineering,Southeast University,Nanjing 211189,China)(2 Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining 810001,China) |
| |
| Abstract: | Against the low bioavailability of the effective ingredients in many chinese herb medicines,solid dispersions(SDs) of 4 different carriers with antihepatitis total glucosides of halenia elliptica D.Don(ATH) were prepared by melt or solvent method,and the dissolution rate was determined by HPLC(high pressure liquid chromatography).According to the results,PEG4000,PEG6000,Poloxamer188 and PVPk30 can be used to prepare SD with ATH.Compared with ATH,the dissolution rate of SDs is increased obviously,and the dis... |
| |
| Keywords: | effective ingredients of chinese herb medicines total glucosides of halenia elliptica solid dispersion dissolution scanning electron microscope |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
