| 心血池显像剂99mTc-HYNIC-HSA的合成及小鼠生物分布研究 |
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| 引用本文： | 杨建权,郭海勋,王学斌.心血池显像剂99mTc-HYNIC-HSA的合成及小鼠生物分布研究[J].北京师范大学学报(自然科学版),2003,39(1):89-95. |
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| 作者姓名： | 杨建权 郭海勋 王学斌 |
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| 作者单位： | 北京师范大学化学系,100875,北京 |
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| 摘 要： | 合成了双功能联结剂肼基烟酰胺（HYNIC），经过了^1HNMR的确认。用HYNIC与人血清白蛋白（HSA）偶联，经过透析纯化后得到HYNIC－HSA。用SnCl2作为还原剂，EDTA作为共配体所制得的^99mTc-HYNIC-HSA的放化纯度高于90％。其小鼠体内生物分布实验表明^99mTc-HYNIC-HSA在血液内的摄取和滞留情况明显优于其他方法标记的HSA，与已用于临床的^99mTc-DMP-HSA相似，是一种很有潜力的新型心血池显像剂。
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| 关 键 词： | 心血池显像剂 双功能联结剂 肼基烟酰胺（HYNIC） HYNIC－HSA ^99mTc－HYNIC－HSA |
| 修稿时间： | 2002年7月9日 |
A STUDY ON THE SYNTHESIS AND BIODISTRIBUTION IN MICE FOR 99mTc-HYNIC-HSA AS A NEW BLOOD POOL IMAGING AGENT |
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| Yang JianquanGuo HaixunWang Xuebin.A STUDY ON THE SYNTHESIS AND BIODISTRIBUTION IN MICE FOR 99mTc-HYNIC-HSA AS A NEW BLOOD POOL IMAGING AGENT[J].Journal of Beijing Normal University(Natural Science),2003,39(1):89-95. |
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| Authors: | Yang JianquanGuo HaixunWang Xuebin |
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| Abstract: | The precursor of bifunctional ligand HYNIC(Hydrazino Nico tinamide)is synthesized and it is characterized by 1HNMR. The HYNIC is coupled with HSA and then a BFCA-biomolecular compound is prepared. The HYNIC- HSA is labelled at pH=6.0, and the labeling yield could reach 91%. The biodistribut ion in mice indicates that 99mTc-HYNIC-HSA is a very promising new blood pool imaging agent. |
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| Keywords: | blood pool imaging agent bifunctional ligand HYNIC HYNIC-HSA 99mTc-HYNIC-HSA |
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