| 99mTcN-GLA的制备及其生物分布研究 |
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| 引用本文： | 张俊波,王学斌,于恺.99mTcN-GLA的制备及其生物分布研究[J].北京师范大学学报(自然科学版),2001,37(2):230-232. |
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| 作者姓名： | 张俊波 王学斌 于恺 |
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| 作者单位： | 北京师范大学化学系, |
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| 基金项目： | 北京市科委科研项目;953304300; |
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| 摘 要： | 将99mTcO-4与浓HCl和NaN3在沸水浴的条件下制备99mTcNCl-4中间体，然后与配体葡萄糖二酸(GLA)发生交换反应得到放化纯度大于90％的99mTcN-GLA配合物.小鼠体内生物分布结果显示: 99mTcN-GLA与99mTc-GLA有明显不同的生物分布，特别是99mTcN-GLA的肺摄取及滞留均较好，有望成为一种新型的肺显像剂.
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| 关 键 词： | 锝－99m 葡萄糖二酸 锝氮核 放射性药物 生物分布 制备 肺显像剂 急性心肌梗塞 |
| 修稿时间： | 2000年11月13日 |
PREPARATION AND BIODISTRIBUTION OF 99mTcN-GLA |
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| Zhang Junbo,Wang Xuebin,YU Kai.PREPARATION AND BIODISTRIBUTION OF 99mTcN-GLA[J].Journal of Beijing Normal University(Natural Science),2001,37(2):230-232. |
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| Authors: | Zhang Junbo Wang Xuebin YU Kai |
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| Abstract: | 99mTcN-GLA (GLA: glucaric acid) is prepared through a ligand-exchange reaction. The two-step procedure involves the initial reaction of 99mTcO-4 with sodium azide(NaN3) and concentrated hydrochloric acid at 100℃ to form the intermediate(99mTcNCl-4), followed by the addition of the ligand GLA. The radiochemical purity (RCP) of the product is over 90％ by TLC. The biodistribution results in mice indicate that the presence of 99mTc nitrido group significantly alters the biological properties of the 99mTc-complex formed using the same ligand. 99mTcN-GLA has good lung uptake and retention, suggesting that it will be a potential lung imaging agent. |
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| Keywords: | technetium-99m glucaric acid technetium nitrido core radiopharmaceutical biodistribution |
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