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| 2,2,6,6-四甲基-4-哌啶酮对小白鼠血清α-甘露糖苷酶的影响 | |
| 引用本文： | 谭远友,王建华,李勤凡,洪子鹂,高巨星,郭庆宏.2,2,6,6-四甲基-4-哌啶酮对小白鼠血清α-甘露糖苷酶的影响[J].武汉科技学院学报,2002,15(1):69-71. |
| 作者姓名： | 谭远友 王建华 李勤凡 洪子鹂 高巨星 郭庆宏 |
| 作者单位： | 1. 武汉科技学院,环境科学研究所,湖北,武汉,430073 2. 西北农林科技大学,陕西,杨凌,712100 3. 陕西省畜牧兽医总站,陕西,西安,710014 |
| 基金项目： | 陕西省援藏课题(0060C8). |
| 摘 要： | 体外试验表明，2，2，6，6-四甲基-4-哌啶酮（TMPD）对小鼠血清α-甘露糖苷酶（AMA）活性（以水解对硝基苯基-α-D-甘露糖苷产生对硝基酚计）具有明显的抑制作用；体内试验用剂量为200、300和400mg/kgBW的TMPD给小鼠每日灌胃一次，分别于第1、2、5、10、20、30、35d采集血液，测定血清AMA活性，结果表明：这3个剂量的TMPD均显著地抑制该酶活性，随TMPD浓度的增加，抑制率相应增加，而灌胃次数增加，酶活性反而有不同程度回升，但不能恢复到初始水平。 |
| 关 键 词： | 生物碱 2 2 6 6－四甲基－4－哌啶酮 α－甘露糖苷酶 小鼠 家畜 中毒 |
| 文章编号： | 1009-5160(2002)01-0069-03 |
| 修稿时间： | 2001年10月9日 |
Effects of 2,2,6,6-tetramethyl-4-piperidone on Serum Alpha-mannosidase of Mouse |
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| TAN Yuan-you,WANG Jian-hua,LI Qing-fan,HONG Zhi-li,GAO Ju-xing,GUO Qing-hong.Effects of 2,2,6,6-tetramethyl-4-piperidone on Serum Alpha-mannosidase of Mouse[J].Journal of Wuhan Institute of Science and Technology,2002,15(1):69-71. | |
| Authors: | TAN Yuan-you WANG Jian-hua LI Qing-fan HONG Zhi-li GAO Ju-xing GUO Qing-hong |
| Institution: | TAN Yuan-you1,WANG Jian-hua2,LI Qing-fan2,HONG Zhi-li3,GAO Ju-xing3,GUO Qing-hong3 |
| Abstract: | tetramethyl-4-piperidone (TMPD) inhabits mouse serum alpha-mannosidase (AMA) activity (measured by the release of P-nitrophenol from P-nitrophengl-alpha-manpyrannoside) in vitro. Mice are individually fed with TMPD at dosages of 200, 300 and 400 milligrams per kilogram body weight once a day respectively, within 1, 2, 5, 10, 20 and 30 days of initial treatment. The treated animals are killed and their serum are collected for AMA activity measurement. The result shows that the AMA activity is markedly decreased within 24 hours of initial treatment. The higher the TMPD concentration, the lower the enzyme activity. And decreased serum AMA activities increases in varying degrees in the flowing days, but could not return to normal. |
| Keywords: | alkaloid 2 2 6 6-tetramethyl-4-piperidone alpha-mannosidase mouse |
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