首页 | 本学科首页   官方微博 | 高级检索  
     检索      

大豆黄酮对衰老小鼠脑组织神经递质含量的调节
引用本文:才金玲,单群,陆军,郑元林.大豆黄酮对衰老小鼠脑组织神经递质含量的调节[J].天津科技大学学报,2011,26(6):16-19.
作者姓名:才金玲  单群  陆军  郑元林
作者单位:1. 天津市海洋资源与化学重点实验室,天津科技大学海洋科学与工程学院,天津300457
2. 徐州师范大学生命科学学院,徐州,221116
基金项目:天津市海洋资源与化学重点实验室开放基金课题,天津科技大学引进人才科研启动基金
摘    要:研究大豆黄酮对D–半乳糖致衰老小鼠脑神经递质水平的调节.连续背部注射D–半乳糖6周,建立衰老模型,然后灌胃大豆黄酮5周(实验组Ⅰ、Ⅱ的剂量分别为5、10 mg/(kg.d)),监测不同脑区乙酰胆碱、乙酰胆碱酯酶、多巴胺和5–羟色胺含量变化,探讨大豆黄酮对衰老小鼠脑组织神经递质水平的影响.结果表明,灌胃衰老小鼠大豆黄酮后,大脑皮质和海马中乙酰胆碱、乙酰胆碱酯酶、多巴胺和5–羟色胺含量明显上升,并且具有一定的剂量效应.说明大豆黄酮可以改善衰老小鼠脑组织中神经递质含量,具有明显的抗衰老作用.

关 键 词:大豆黄酮  抗衰老  乙酰胆碱  乙酰胆碱酯酶  多巴胺  5–羟色胺

Regulation of Daidzein on Neurotransmitter Levels in Brain of Aged Mice
CAI Jin-ling,SHAN Qun,LU Jun,ZHENG Yuan-lin.Regulation of Daidzein on Neurotransmitter Levels in Brain of Aged Mice[J].Journal of Tianjin University of Science & Technology,2011,26(6):16-19.
Authors:CAI Jin-ling  SHAN Qun  LU Jun  ZHENG Yuan-lin
Institution:CAI Jin-ling1,SHAN Qun2,LU Jun2,ZHENG Yuan-lin2(1.Tianjin Key Laboratory of Marine Resources and Chemistry,College of Marine Science and Engineering,Tianjin University of Science & Technology,Tianjin 300457,China,2.School of Life Science,Xuzhou Normal University,Xuzhou 221116,China)
Abstract:To observe daidzein on the effects of D-galactose induced senescence in mice,D-galactose was injected in the dorsal of mice for 6 weeks as an aged model.The aged mice were fed daidzein with the doses 5 mg/(kg.d)(Test Ⅰ)and 10 mg/(kg.d)(Test Ⅱ)for 5 weeks.The levels of acetylcholine,acetylcholinesterase,dopamine,and 5-hydroxytryptamine in brain of the aged mice were examined.The results showed that daidzein could increase acetylcholinea,cetylcholinesterase,dopamine,and 5-hydroxytryptamine levels in cortex and hippocampus of aged mice.Daidzein could increase neurotransmit-ter levels of the mice’s brain and have antisenecence in some degree.
Keywords:daidzein  antisenescence  acetylcholine  acetylcholinesterase  dopamine  5-hydroxytryptamine  
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号