雀麦膳食纤维对2型糖尿病模型大鼠血糖、血脂影响的研究

目的探讨雀麦膳食纤维粉（Oats dietary fiber bran，ODFB）对2型糖尿病（type 2 diabetes mellitus，T2DM）模型大鼠血糖、血脂的影响.方法将Wister大鼠50只（体质量为194.5±5.3g）随机分5组，每组雌雄各半：A组为阴性对照组，10只，喂饲基础饲料；另40只为糖尿病模型组，制成T2DM大鼠模型，再随机分为B，C，D，E 4组.每组10只即.B（糖尿病对照组即阳性对照组）组继续喂饲高糖、高脂饲料，C，D及E组喂饲分别加入含DF30%、40%和60%的ODFB高糖、高脂饲料，8W后观察DF对大鼠糖代谢、脂代谢和食物利用率的影响.结果①与B组相比，C，D和E组动物食物利用率明显增加；②三个剂量组均有明显的降低空腹血糖（Fasting blood glu-cose，FBG）、血清甘油三酯（Triglycerides，TG）、总胆固醇（Total cholesterol，TC）、低密度脂蛋白胆固醇（Low densitylipid-cholesterol，LDL-C），同时升高高密度脂蛋白胆固醇（High density lipid-cholesterol，HDL-C）水平的作用，而D，E作用更显著；③与B组比较，C，D，E三组糖耐量曲线下面积明显减少；D，E两组血糖水平已接近阴性对照组（A组）水平.结论一定剂量的ODFB有改善T2DM大鼠模型食物利用率、降糖和降脂作用.

Effects of Dietary Fiber in Oat Bran on Blood Glucose and Blood Lipid in Experimental Type-2 Diabetes Mellitus Rats

Objective To study the effects of dietary fiber （DF） in Oat bran on blood glucose and blood lipid in rats with experiment type-2 diabetes mellitus. Methods 50 wistar rats（194.4±5.3g） are divided into 5 groups base on their body weight. Every group has 10 rats （half male and half female）. The control group （group A） is fed normal diet. The other four groups are injected with lower dose （25mg/kg bw） of streptozotocin （STZ） and fed a diet with high calorie and high fat. After formation of the diabetes model, week the three concentration of DF all decrease fasting group B （T2DM model group） is fed a diet with high calorie and high fat, and group C, D, E are fed 30% DF, 40% DF and 60% DF respectively. The effects of DF on metabolism of glucose and lipid , and availability of food are observed. Results （1）The difference of food availability is statistically significant. Compared group B with the other four groups respectively , the differences are all significant （2）Before the injection of STZ （0W）, the level of blood glucose and lipid in every group are statistically same. But on the eighth blood glucose （FBG）, Triglycerides, （TG）, Total cholesterol（TC）, and Low density lipid-cholesterol （LDL-C）, significantly, and increase High density lipid-cholesterol （HDL-c） at the same time. The effects of 40%, 60% DF stronger than 30% DF. （3）The glucose tolerance curve of every group is significantly different. The curve of group A and B are steep, while group C,D and E are relatively smooth. Conclusion DF can decrease the blood glucose and blood lipid.