金花茶叶水提物的降脂功能试验研究

用高脂饲料喂养Wistar大鼠15d，造成大鼠高血脂症模型，然后分别灌胃(ig)给予金花茶叶水提物每天0．8，0．4，0．2g／kg，以临床降血脂药物洛伐他汀(0．01g／kg)为阳性对照．灌胃实验第43天后取血清测定总胆固醇(TC)和甘油三酯(TG)、高密度脂蛋白(HDL—C)和低密度脂蛋白(LDL—C)．结果金花茶叶水提物高、中剂量组均能降低高血脂症模型大鼠血清中TC、TG和LDL—C含量，效果与阳性对照药洛伐他汀相当，与高脂对照组比较，经t检验，差异均有显著性意义；高剂量组和洛伐他汀还能升高高血脂症模型大鼠血清中HDL—C含量．表明金花茶叶水提物具有明显的降血脂作用．

The experimental study on regulating serum lipid of water soluble extractive from the leave of Camellia chrysantha (Hu) Tuyama

To observe the effects on regulating serum lipid by the water soluble extractive.Wistar rats were fed by hyperlipids food 15 days to induce hyperlipidemia,and then gastrogavaged respectively with 0.8,0.4,0.2 g/kg per day the water soluble extractive. The positive group rats were treated with Lovastatin(0.01 g/kg).At the forty-third day,serum total cholesterol (TC),triglycerides (TG),high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were mensurated. Results In the same experimental conditions,The high and medial dose of water soluble extractive could decrease the content of serum TC,TG and LDL-C in hyperlipidemia rats and the high dose group and Lovastatin dose group could increase the content of serum HDL-C.Its effects of regulating serum lipid was about equal to the Lovastatin.The treated groups have statistical significance compared with hyperlipid- aemic group by t-test.The water soluble extractive from the leave of Camellia chrysantha (Hu) Tuyama has the obvious effects on regulating serum lipid.