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| 熊果酸在神经精神系统疾病中的药理作用及机制研究进展 | |
| 引用本文： | 石亚静,冷玉芳,陈凤,张健民,任以行,刘馨.熊果酸在神经精神系统疾病中的药理作用及机制研究进展[J].科技导报(北京),2021,39(13):117-124. |
| 作者姓名： | 石亚静 冷玉芳 陈凤 张健民 任以行 刘馨 |
| 作者单位： | 1. 兰州大学第一临床医学院, 兰州 730000; 2. 兰州大学第一医院麻醉科, 兰州 730000 |
| 摘 要： | 熊果酸（ursolic acid，UA）是一种五环三萜类化合物，存在于熊果、女贞叶、枇杷叶等植物中。熊果酸不仅具有抗氧化、抗炎、抗肿瘤、抗糖尿病、保肝等药理活性，还具有改善和治疗多种神经精神系统疾病的作用。通过文献分析，归纳总结了熊果酸在神经元损伤、脑血管疾病和精神障碍中的药理作用及其作用机制的研究进展。 |
| 关 键 词： | 熊果酸 神经精神系统疾病 神经保护 |
| 收稿时间： | 2020-03-19 |
Research progress on pharmacological role and mechanism of ursolic acid in nervous-mental system diseases |
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| SHI Yajing,LENG Yufang,CHEN Feng,ZHANG Jianmin,REN Yixing,LIU Xin.Research progress on pharmacological role and mechanism of ursolic acid in nervous-mental system diseases[J].Science & Technology Review,2021,39(13):117-124. | |
| Authors: | SHI Yajing LENG Yufang CHEN Feng ZHANG Jianmin REN Yixing LIU Xin |
| Institution: | 1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; 2. Department of Anesthesiology, the First Hospital of Lanzhou University, Lanzhou 730000, China |
| Abstract: | Ursolic acid (UA) is a kind of pentacyclic triterpene acid compound found in a variety of plants, such as bearberries, privet leaves, and loquat leaves. In addition to the pharmacological effects of anti-oxidative, anti-inflammatory, anti-cancer, anti-diabetic, and hepatoprotective, UA also has the function of improving and treating many kinds of diseases in nervous-mental system. In this paper, the role of UA in neuronal injury, cerebrovascular diseases as well as mental disorders and its research mechanisms are summarized by literature analysis so as to provide reference for subsequent research and clinical application of UA in nervous-mental system diseases. |
| Keywords: | ursolic acid nervous-mental system diseases neuroprotection |
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