中药“十八反”的历史沿革、宜忌争论与思考建议

 为分析“十八反”的历史沿革及研究现状、提出下一步开展“十八反”研究的建议, 回顾了“相反”理论的提出、“十八反”歌诀的出现、目前药典对“十八反”的相关规定。从文献记载、临床报道、实验研究３个方面论述了关于“十八反”的宜忌争论。分析整理文献、总结“十八反”在临床研究和实验研究方面的进展, 可以看出临床方面的研究多是从文献的角度, 进行回顾性总结, 从中挖掘整理“十八反”反药组合的临床安全性评价和配伍应用规律。而关于“十八反”的实验研究则主要从化学物质基础、药理学、毒理学等方面开展。

Historical evolution,incompatibility arguments and suggestions on “eighteen incompatible medicaments”

This paper reviews the antagonism theory and "eighteen incompatible medicaments", as well as the relevant provisions about them in the Pharmacopoeia of China. It provides suggestions for further research concerning the "eighteen incompatible medicaments" through analysis of their historical evolution and the status quo. The incompatibility arguments of the "eighteen incompatible medicaments" are discussed from aspects of literature review, experimental studies and clinical reports. It is found that clinical studies focus on retrospective summary of clinical reports, analyzing clinical safety evaluation and rules of compatible applications. Experimental studies are mostly carried out from aspects of chemical material foundation, pharmacology and toxicology.