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| T细胞抑制性受体及其免疫调节作用 | |
| 引用本文： | 王帅威,罗雪瑞,李扬扬,林芳,李丹,袁晓君,李斌.T细胞抑制性受体及其免疫调节作用[J].科技导报(北京),2015,33(18):84-90. |
| 作者姓名： | 王帅威 罗雪瑞 李扬扬 林芳 李丹 袁晓君 李斌 |
| 作者单位： | 1. 上海大学生命科学学院;上海市能源作物育种及应用重点实验室, 上海 200444; 2. 中国科学院上海巴斯德研究所, 分子病毒与免疫学重点实验室, 上海 200031 |
| 基金项目： | 国家重点基础研究计划(973计划)项目(2014CB541803,2014CB541903);国家自然科学基金项目(31200647,81330072,31370863,31170825,81271835,31200646,81302532,31300711);上海市学术委员会基础研究重大重点项目(14JC1406100);国家科技重大专项(2012ZX10002007-003) |
| 摘 要： | T 淋巴细胞在免疫系统中发挥细胞免疫、免疫调节等功能。然而, T 细胞的过度激活会导致疾病(如哮喘、系统性红斑狼疮等)的发生, 抑制T 细胞的过度激活是免疫治疗的重要研究方向。T 细胞抑制性受体可通过与其配体结合调控T 细胞增殖或功能发挥, 并在过敏性疾病、移植排斥等治疗中作为治疗靶点。因此, 进一步解析T 细胞抑制性受体的三维结构、配体-受体复合物组分及其下信游号通路将有助于免疫治疗的发展。本综述总结了GITR、CTLA-4、BTLA、PD-1、LAIR-1、TIM-3、TIGIT 等T 细胞抑制性受体的生理生化特性、与其配体结合后对T 细胞免疫功能的调节以及抗体药物的研究进展。 |
| 关 键 词： | T 细胞 抑制性受体 免疫调节 |
| 收稿时间： | 2015-03-11 |
Immune regulatory function of T cell-inhibitory receptors |
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| WANG Shuaiwei,LUO Xuerui,LI Yangyang,LIN Fang,LI Dan,YUAN Xiaojun,LI Bin.Immune regulatory function of T cell-inhibitory receptors[J].Science & Technology Review,2015,33(18):84-90. | |
| Authors: | WANG Shuaiwei LUO Xuerui LI Yangyang LIN Fang LI Dan YUAN Xiaojun LI Bin |
| Institution: | 1. Shanghai Key Laboratory of Bio-energy Crops, College of Life Science, Shanghai University, Shanghai 200444, China; 2. Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China |
| Abstract: | T lymphocytes play a fundamental role in cellular immune and immune regulation in immune system. However, the overactivation of T cells may induce many diseases including asthma, systemic lupus-erythematosus. It is crucial to control the T cell over-activation in the immunotherapy field. The inhibitory receptors of T cells can regulate proliferation and function of T cells by contacting with their ligands. Latest studies have indicated that T cell inhibitory receptors targeting therapy can attenuate the symptoms of diseases and graft rejection. Intensive study on the regulation of T cells would provide effective strategies for preventing and treating immune diseases. |
| Keywords: | T lymphocyte inhibitory receptor immune regulation |
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