马钱子及其活性成分临床应用研究进展

马钱子中可以提取出士的宁、马钱子碱、环烯醚萜苷等多种具有生物活性的化合物。综述了马钱子主要提取物在神经系统、免疫系统、肌肉骨骼系统、抑制病原微生物和抗肿瘤方面的药理机制，并分析了其活性成分的临床应用价值。结果发现马钱子活性成分具有可兴奋中枢神经系统，提高感觉器官的功能，有效减轻炎症反应，有较强的镇痛抗炎功能，此外还对多种肿瘤具有抑制效果，未来有望开发成为抗血管增生和抗癌治疗药物。

Research progress on clinical application of nux-vomica

Strychnos nuxvomica L. is a traditional Chinese medicine, which has the effect of relieving pain and reducing swelling. Modern pharmacological studies have found that strychnine, brucine, iridoid glycosides and other bioactive compounds can be extracted from Semen Strychni. To understand the clinical value of nux vomica and its active ingredients, we collected relevant research results, explored the pharmacological mechanisms of its main extract in nervous system, immune system, musculoskeletal system, inhibiting pathogenic microorganisms and anti-tumor, respetively, and then analyzed the clinical application value The results show that the active components of nux vomica can excite the central nervous system, improve the function of sensory organs, reduce inflammation effectively, ease pain, and reduce inflammation, in addition to playing a role of inhibiting a variety of tumors. Possibly, it can be developed as anti-angiogenic and anticancer drugs in the future. With the indepth study of the pharmacological mechanism of nux vomica, more confirmed evidences of pharmacology and experiment will bemastered to guide the clinical application.