干扰素在猪黏膜免疫应答中的研究进展

 黏膜免疫系统是动物产生免疫应答的物质基础，参与机体免疫应答并发挥着重要的功能。猪群接种免疫疫苗后，疫苗经黏膜免疫系统可产生黏膜抗体并激活全身性免疫应答，干扰素参与早期黏膜免疫，具有抗病毒及免疫调节等多种生物学功能。从不同种类的猪干扰素和免疫系统的相关性角度出发，阐述猪干扰素对黏膜免疫的调节作用。重点综述了干扰素与黏膜免疫系统、猪干扰素对免疫系统的调节作用及干扰素作为黏膜免疫佐剂的研究现状，旨在为猪干扰素作为黏膜免疫佐剂的研制提供参考。

Overview on interferon in the mucosa immune response of pig mucosal immunity

The animal mucosal immune system serves as the material basis of the immune response, and plays an important role. The vaccine is induced by the mucosal antibody derived from the mucosal immune system, followed by the activated systemic immune response. The interferon acts as a potential mucosal immune adjuvant involved in many biological functions, such as antivirus and immune regulation. This paper reviews the correlation between the mucosal innate immunity and the porcine interferon, focusing on the immunomodulatory roles of the mucosal immune system, the porcine interferon signaling pathway and the immunologic adjuvant, to provide a reference for the development of the porcine interferon as a mucosal immune adjuvant.