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| 人工酶与定向进化的前沿与挑战 | |
| 引用本文： | 于洋,王江云.人工酶与定向进化的前沿与挑战[J].科技导报(北京),2020,38(8):101-105. |
| 作者姓名： | 于洋 王江云 |
| 作者单位： | 1. 北京理工大学化学与化工学院, 北京 100081; 2. 中国科学院生物物理研究所, 北京 100101 |
| 基金项目： | 国家重点研发计划项目（2018YFA0903300），国家自然科学基金项目（21750003） |
| 摘 要： | 定向进化是在实验室环境中，在分子水平上模拟进化过程，得到具有期望特征的蛋白质的方法，目前已成为蛋白质设计改造的重要方法。定向进化不仅可以用于天然蛋白质的改造，也可以通过改造现有的酶，使其具有新的催化活性，从而构建人工酶。本文重点介绍工业生物催化、纳米酶设计和光催化3个方向的前沿成果，并讨论人工酶与定向进化领域存在的挑战和问题。 |
| 关 键 词： | 人工酶 定向进化 工业生物催化 纳米酶 光催化 |
| 收稿时间： | 2019-11-27 |
Frontiers and challenges of artificial enzyme and directed evolution |
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| YU Yang,WANG Jiangyun.Frontiers and challenges of artificial enzyme and directed evolution[J].Science & Technology Review,2020,38(8):101-105. | |
| Authors: | YU Yang WANG Jiangyun |
| Institution: | 1. School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China; 2. Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China |
| Abstract: | The directed evolution is a method to obtain proteins with desired traits by mimicking the evolution process at the molecular level in a lab environment. It is an important method for protein design and engineering. Apart from the engineering natural proteins, the directed evolution can be used to construct artificial enzymes by modifying the existing enzymes to have new catalytic activities. This paper reviews the recent studies of the industrial biocatalysis, the nanozyme design and the photocatalysis, as well as the challenges and the problems in the field of the directed evolution and the artificial enzyme. |
| Keywords: | artificial enzyme directed evolution industrial biocatalysis nanozyme photocatalysis |
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