通向超低成本肿瘤治疗之路的高强度热化学靶向消融方法

高温热疗是继放疗、化疗之后一种十分重要的肿瘤治疗手段。从特定化学物质与生物体内的目标组织发生反应,从而实现靶向释放热量的思想出发,建立了系列高强度热化学消融方法,可有效克服传统加热方式中普遍存在的设备复杂、价格高昂、靶向性不强、使用时易引起正常组织烫伤等问题。对其中比较典型的酸碱中和反应热消融法及碱金属热消融法的原理、特点、前景进行了分析。

Way to Ultra Low Cost Tumor Hyperthermia Treatment: Targeted High Intensity Thermochemical Ablation Therapy

Hyperthermia has long been an important tumor treatment modality, ranked only after radiotherapy and chemotherapy. A series of targeted high intensity thermochemical ablation techniques have been successfully established, starting from some basic operations of localizing release of heat energy during a chemical reaction by some specific chemicals and partial ingredients of biological tissues, which can effectively overcome the ubiquitous shortcomings and problems encountered by conventional heating methods, such as requiring complex structures in equipment, expensive in price, with poor target property, and prone to thermal damages to healthy tissues. The basic principles and features of two typical thermochemical ablation methods (acid-alkali reaction enabled thermal ablation and alkali metal enabled thermal ablation) are comprehensively reviewed and the prospects of these techniques are analyzed.